Efficacy of one-week triple antimicrobial therapy (bismuth, tinidazole, amoxicillin) as compared to the same drug combination given for 4 weeks was assessed in children,vith Helicobacter pylori (H.pylori) gastritis and non-ulcer dyspepsia, Twenty-six patients (group A) and 30 (group B) had one-week and four-week schedule, respectively, Eradication (absence of organism at endoscopy at least 1 month after ending treatment) was achieved in 84.6% of group A (22) and 83.3% of group B (25), with marked reduction of histological gastritis score in both groups, Among patients,vith eradicated H.pylori, symptoms improved significantly in 14 and 16 patients of group A and B, respectively, but were still present in 17 (8 of group A, 9 group B), The latter showed gastroparesis and abnormal gastro-oesophageal reflux at a subsequent diagnostic work-up and improved with prokinetic therapy, In 3 patients of group A and 3 of group B, symptoms improved despite persistence of bacterium into the stomach, Finally, in 3 cases (1 group A, 2 group B) both symptoms and H.pylori infection were unchanged, At 6 month follow-up, symptoms were present in 7 patients (3 group A, 4 group B): 6 of them (3 group A, 3 group B) showed H.pylori gastritis at endoscopy, We conclude that in children with dyspepsia and H.pylori gastritis one-week triple antimicrobial schedule is effective in eradicating bacterium; however, detection of H.pylori gastritis in dyspeptic children does not invariably indicate a pathogenetic role of the organism in these patients.

Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism / Cucchiara, Salvatore; G., Salvia; N., Az Zeqeh; F., D'Armiento; M. R., De Petra; S., Rapagiolo; A., Campanozzi; M., Emiliano. - In: ITALIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0392-0623. - ELETTRONICO. - 28:8(1996), pp. 430-435. (Intervento presentato al convegno 28th Annual Meeting of the European-Society-for-Paediatric-Gastroenterology-and-Nutrition tenutosi a JERUSALEM, ISRAEL nel MAY 28-JUN 01, 1995).

Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism

CUCCHIARA, Salvatore;
1996

Abstract

Efficacy of one-week triple antimicrobial therapy (bismuth, tinidazole, amoxicillin) as compared to the same drug combination given for 4 weeks was assessed in children,vith Helicobacter pylori (H.pylori) gastritis and non-ulcer dyspepsia, Twenty-six patients (group A) and 30 (group B) had one-week and four-week schedule, respectively, Eradication (absence of organism at endoscopy at least 1 month after ending treatment) was achieved in 84.6% of group A (22) and 83.3% of group B (25), with marked reduction of histological gastritis score in both groups, Among patients,vith eradicated H.pylori, symptoms improved significantly in 14 and 16 patients of group A and B, respectively, but were still present in 17 (8 of group A, 9 group B), The latter showed gastroparesis and abnormal gastro-oesophageal reflux at a subsequent diagnostic work-up and improved with prokinetic therapy, In 3 patients of group A and 3 of group B, symptoms improved despite persistence of bacterium into the stomach, Finally, in 3 cases (1 group A, 2 group B) both symptoms and H.pylori infection were unchanged, At 6 month follow-up, symptoms were present in 7 patients (3 group A, 4 group B): 6 of them (3 group A, 3 group B) showed H.pylori gastritis at endoscopy, We conclude that in children with dyspepsia and H.pylori gastritis one-week triple antimicrobial schedule is effective in eradicating bacterium; however, detection of H.pylori gastritis in dyspeptic children does not invariably indicate a pathogenetic role of the organism in these patients.
1996
dyspepsia; gastric emptying; gastritis; helicobacter pylori
01 Pubblicazione su rivista::01a Articolo in rivista
Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism / Cucchiara, Salvatore; G., Salvia; N., Az Zeqeh; F., D'Armiento; M. R., De Petra; S., Rapagiolo; A., Campanozzi; M., Emiliano. - In: ITALIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0392-0623. - ELETTRONICO. - 28:8(1996), pp. 430-435. (Intervento presentato al convegno 28th Annual Meeting of the European-Society-for-Paediatric-Gastroenterology-and-Nutrition tenutosi a JERUSALEM, ISRAEL nel MAY 28-JUN 01, 1995).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/98616
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