Abstract Background: The growth of new therapeutic options and practices increases the risk of Hepatitis B virus (HBV) reactivation in patients with haematological malignancies and/or patients undergoing haematological stem cell transplantation (HSCT).Objectives: To provide a systematic review supporting recommendations for prevention, monitoring, prophylaxis and therapy of HBV reactivation in patients with haematological malignancies and HSCT. Data sources: The systematic review was based on a search strategy using PubMed and the Cochrane Library from 1991 to December 31, 2016. PRISMA guidelines were followed. Selection criteria: Randomized control trials, prospective and retrospective cohort studies. Risk-of-bias assessment: The risk of bias was assessed using the Cochrane risk of bias tool and the Newcastle Ottawa Scale. Results: 42 studies of fair or good quality were included in this systematic review. The main results obtained are: 1. haematologic patients should be screened for HBV before CHT; 2. HBV DNA levels should be monthly monitored in all HBV-positive patients not receiving prophylaxis; 3. HBsAg-positive haematologic patients and patient underwent HSCT should receive prophylaxis and third-generation HBV drugs should be given 4. anti-HBc-positive lymphoma patients and patients underwent HSCT should receive antiviral prophylaxis. Conclusions: A higher quality of evidence is needed, however the level of evidence was sufficient to support the recommendations published in the same issue of this journal

Screening, monitoring, prevention, prophylaxis and therapy for Hepatitis B virus reactivation in patients with haematological malignancies and patients who underwent haematological stem cell transplantation: a systematic review / Gentile, Giuseppe; Andreoni, M; Antonelli, Guido; Sarmati, L.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - STAMPA. - 12:23(2017), pp. 916-923. [10.1016/j.cmi.2017.06.024]

Screening, monitoring, prevention, prophylaxis and therapy for Hepatitis B virus reactivation in patients with haematological malignancies and patients who underwent haematological stem cell transplantation: a systematic review

GENTILE, Giuseppe
;
ANTONELLI, Guido;
2017

Abstract

Abstract Background: The growth of new therapeutic options and practices increases the risk of Hepatitis B virus (HBV) reactivation in patients with haematological malignancies and/or patients undergoing haematological stem cell transplantation (HSCT).Objectives: To provide a systematic review supporting recommendations for prevention, monitoring, prophylaxis and therapy of HBV reactivation in patients with haematological malignancies and HSCT. Data sources: The systematic review was based on a search strategy using PubMed and the Cochrane Library from 1991 to December 31, 2016. PRISMA guidelines were followed. Selection criteria: Randomized control trials, prospective and retrospective cohort studies. Risk-of-bias assessment: The risk of bias was assessed using the Cochrane risk of bias tool and the Newcastle Ottawa Scale. Results: 42 studies of fair or good quality were included in this systematic review. The main results obtained are: 1. haematologic patients should be screened for HBV before CHT; 2. HBV DNA levels should be monthly monitored in all HBV-positive patients not receiving prophylaxis; 3. HBsAg-positive haematologic patients and patient underwent HSCT should receive prophylaxis and third-generation HBV drugs should be given 4. anti-HBc-positive lymphoma patients and patients underwent HSCT should receive antiviral prophylaxis. Conclusions: A higher quality of evidence is needed, however the level of evidence was sufficient to support the recommendations published in the same issue of this journal
2017
HBV infection; HBV prophylaxis; HBV reactivation; HSCT; Hepatitis B virus; haematological malignancies; haematological stem cell transplantation
01 Pubblicazione su rivista::01a Articolo in rivista
Screening, monitoring, prevention, prophylaxis and therapy for Hepatitis B virus reactivation in patients with haematological malignancies and patients who underwent haematological stem cell transplantation: a systematic review / Gentile, Giuseppe; Andreoni, M; Antonelli, Guido; Sarmati, L.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - STAMPA. - 12:23(2017), pp. 916-923. [10.1016/j.cmi.2017.06.024]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/985222
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