Currently, neoadjuvant fluoropyrimidine-based chemoradiotherapy (CRT) is standard practice in the management of locally advanced rectal cancer (LARC). In the last decade there has been a lively interest in the improvement of clinical outcomes by modifying this standard regimen by the addition of further agents. We review combinations of targeted therapies and conventional CRT currently under investigation in LARC patients.

The addition of target therapy to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a review / Benevento, Ilaria; DE FELICE, Francesca; Musio, Daniela; Tombolini, Vincenzo. - In: CHEMOTHERAPY. - ISSN 0009-3157. - STAMPA. - 62:5(2017), pp. 314-322. [10.1159/000476056]

The addition of target therapy to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a review

BENEVENTO, ILARIA
Co-primo
;
DE FELICE, FRANCESCA
Co-primo
;
TOMBOLINI, Vincenzo
Ultimo
2017

Abstract

Currently, neoadjuvant fluoropyrimidine-based chemoradiotherapy (CRT) is standard practice in the management of locally advanced rectal cancer (LARC). In the last decade there has been a lively interest in the improvement of clinical outcomes by modifying this standard regimen by the addition of further agents. We review combinations of targeted therapies and conventional CRT currently under investigation in LARC patients.
2017
bevacizumab; cetuximab; epidermal growth factor receptor; locally advanced disease; neoadjuvant treatment; preoperative chemoradiotherapy; rectal cancer; target therapy; vascular endothelial growth factor receptor
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The addition of target therapy to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a review / Benevento, Ilaria; DE FELICE, Francesca; Musio, Daniela; Tombolini, Vincenzo. - In: CHEMOTHERAPY. - ISSN 0009-3157. - STAMPA. - 62:5(2017), pp. 314-322. [10.1159/000476056]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/980633
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