Background: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. Materials and Methods: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. Results: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/ adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. Conclusion: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development.

Primary Peritoneal Serous Carcinoma in Men: A Rare and Non-BRCA-associated Entity / Neuhausen, Sl; Shani, H; Boker, Lk; Steele, L; Silverman, Bg; Ottini, Laura; Silvestri, Valentina; Laitman, Y; Korach, J; Perri, T; Friedman, E.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - (2017).

Primary Peritoneal Serous Carcinoma in Men: A Rare and Non-BRCA-associated Entity.

OTTINI, LAURA;SILVESTRI, VALENTINA;
2017

Abstract

Background: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. Materials and Methods: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. Results: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/ adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. Conclusion: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development.
2017
PPSC; Primary peritoneal serous carcinoma; cancer risk; male BRCA mutations; ovarian cancer
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Primary Peritoneal Serous Carcinoma in Men: A Rare and Non-BRCA-associated Entity / Neuhausen, Sl; Shani, H; Boker, Lk; Steele, L; Silverman, Bg; Ottini, Laura; Silvestri, Valentina; Laitman, Y; Korach, J; Perri, T; Friedman, E.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - (2017).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/980249
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