Neuroblastoma is a cancer of the developing sympathetic nervous system that most commonly presents in young children and accounts for approximately 12% of pediatric oncology deaths. Here, we report on a genome-wide association study (GWAS) in a discovery cohort of 2,101 cases and 4,202 controls of European ancestry. We identify two new association signals at 3q25 and 4p16 that replicated robustly in multiple independent cohorts comprising 1,163 cases and 4,396 controls (3q25: rs6441201 combined P = 1.2x10-11, Odds Ratio 1.23, 95% CI:1.16–1.31; 4p16: rs3796727 combined P = 1.26x10-12, Odds Ratio 1.30, 95% CI:1.21–1.40).
Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma / Mcdaniel, Lee D.; Conkrite, Karina L.; Chang, Xiao; Capasso, Mario; Vaksman, Zalman; Oldridge, Derek A.; Zachariou, Anna; Horn, Millicent; Diamond, Maura; Huo, Cuiping; Iolascon, Achille; Hakonarson, Hakon; Rahman, Nazneen; Devoto, Marcella; Diskin, Sharon J.. - In: PLOS GENETICS. - ISSN 1553-7390. - 13:5(2017), p. e1006787. [10.1371/journal.pgen.1006787]
Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma
DEVOTO, MARCELLA;
2017
Abstract
Neuroblastoma is a cancer of the developing sympathetic nervous system that most commonly presents in young children and accounts for approximately 12% of pediatric oncology deaths. Here, we report on a genome-wide association study (GWAS) in a discovery cohort of 2,101 cases and 4,202 controls of European ancestry. We identify two new association signals at 3q25 and 4p16 that replicated robustly in multiple independent cohorts comprising 1,163 cases and 4,396 controls (3q25: rs6441201 combined P = 1.2x10-11, Odds Ratio 1.23, 95% CI:1.16–1.31; 4p16: rs3796727 combined P = 1.26x10-12, Odds Ratio 1.30, 95% CI:1.21–1.40).| File | Dimensione | Formato | |
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