It has been well established that bone fragility is one of the chronic complications of diabetes mellitus, and both type 1 and type 2 diabetes are risk factors for fragility fractures. Diabetes may negatively affect bone health by unbalancing several pathways: bone formation, bone resorption, collagen formation, inflammatory cytokine, muscular and incretin system, bone marrow adiposity and calcium metabolism. The purpose of this narrative review is to explore the current understanding of pathophysiological pathways underlying bone fragility in diabetics. In particular, the review will focus on the peculiar cellular and molecular system impairment that may lead to increased risk of fracture in type 1 and type 2 diabetes.

Pathophysiology of Bone Fragility in Patients with Diabetes / Palermo, Andrea; D'Onofrio, Luca; Buzzetti, Raffaella; Manfrini, Silvia; Napoli, Nicola. - In: CALCIFIED TISSUE INTERNATIONAL. - ISSN 0171-967X. - 100:2(2017), pp. 122-132. [10.1007/s00223-016-0226-3]

Pathophysiology of Bone Fragility in Patients with Diabetes

PALERMO, ANDREA;D'ONOFRIO, LUCA;BUZZETTI, Raffaella;
2017

Abstract

It has been well established that bone fragility is one of the chronic complications of diabetes mellitus, and both type 1 and type 2 diabetes are risk factors for fragility fractures. Diabetes may negatively affect bone health by unbalancing several pathways: bone formation, bone resorption, collagen formation, inflammatory cytokine, muscular and incretin system, bone marrow adiposity and calcium metabolism. The purpose of this narrative review is to explore the current understanding of pathophysiological pathways underlying bone fragility in diabetics. In particular, the review will focus on the peculiar cellular and molecular system impairment that may lead to increased risk of fracture in type 1 and type 2 diabetes.
Diabetes; Hyperglycaemia; Osteoblast; Osteoclast; Osteoporosis; Endocrinology, Diabetes and Metabolism; Orthopedics and Sports Medicine; Endocrinology
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Pathophysiology of Bone Fragility in Patients with Diabetes / Palermo, Andrea; D'Onofrio, Luca; Buzzetti, Raffaella; Manfrini, Silvia; Napoli, Nicola. - In: CALCIFIED TISSUE INTERNATIONAL. - ISSN 0171-967X. - 100:2(2017), pp. 122-132. [10.1007/s00223-016-0226-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/972317
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