Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always / Georg, Birgitte; Ghelli, Anna; Giordano, Carla; Ross Cisneros, Fred N.; Sadun, Alfredo A.; Carelli, Valerio; Hannibal, Jens; La Morgia, Chiara. - In: MITOCHONDRION. - ISSN 1567-7249. - STAMPA. - 36:(2017), pp. 77-84. [10.1016/j.mito.2017.04.003]

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

GIORDANO, Carla;
2017

Abstract

Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.
2017
alzheimer; dominant optic atrophy; Leber's hereditary optic neuropathy; light; melanopsin; mitochondria; optic atrophy; retinal ganglion cells; robustness; molecular medicine; molecular biology; cell biology
01 Pubblicazione su rivista::01a Articolo in rivista
Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always / Georg, Birgitte; Ghelli, Anna; Giordano, Carla; Ross Cisneros, Fred N.; Sadun, Alfredo A.; Carelli, Valerio; Hannibal, Jens; La Morgia, Chiara. - In: MITOCHONDRION. - ISSN 1567-7249. - STAMPA. - 36:(2017), pp. 77-84. [10.1016/j.mito.2017.04.003]
File allegati a questo prodotto
File Dimensione Formato  
Georg_postprint_Melanopsin_2017.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 1.7 MB
Formato Adobe PDF
1.7 MB Adobe PDF
Georg_Melanopsin-expressing retina_2017.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 832.78 kB
Formato Adobe PDF
832.78 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/970756
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 13
social impact