Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.

T1 mapping for characterization of Intracellular and extracellular myocardial diseases in heart failure / Maestrini, Viviana; Treibel, Thomas A.; White, Steven K.; Fontana, Marianna; Moon, James C.. - In: CURRENT CARDIOVASCULAR IMAGING REPORTS. - ISSN 1941-9066. - 7:9(2014). [10.1007/s12410-014-9287-8]

T1 mapping for characterization of Intracellular and extracellular myocardial diseases in heart failure

MAESTRINI, VIVIANA
Primo
;
2014

Abstract

Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.
2014
cardiac remodelling; diffuse fibrosis; extracellular space; extracellular volume fraction; heart failure; interstitium; intracellular space; myocardial intracellular volume; myocytes; t1 mapping; cell biology; histology; applied microbiology and biotechnology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
T1 mapping for characterization of Intracellular and extracellular myocardial diseases in heart failure / Maestrini, Viviana; Treibel, Thomas A.; White, Steven K.; Fontana, Marianna; Moon, James C.. - In: CURRENT CARDIOVASCULAR IMAGING REPORTS. - ISSN 1941-9066. - 7:9(2014). [10.1007/s12410-014-9287-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/970052
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