Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.
Functional characterization of human thyroid tissue with immunohistochemistry / Faggiano, Antongiulio; Bernard, Caillou; Ludovic, Lacroix; Monique, Talbot; Filetti, Sebastiano; Jean Michel Bidart, ; Martin, Schlumberger. - In: THYROID. - ISSN 1050-7256. - 17:3(2007), pp. 203-211. [10.1089/thy.2006.0174]
Functional characterization of human thyroid tissue with immunohistochemistry
Antongiulio Faggiano;FILETTI, SEBASTIANO;
2007
Abstract
Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.| File | Dimensione | Formato | |
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