Four pyrrolizidine alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276–0.769.
Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy / Benamar, Houari; Tomassini, Lamberto; Venditti, Alessandro; Marouf, Abderrazak; Bennaceur, Malika; Serafini, Mauro; Nicoletti, Marcello. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 31:11(2017), pp. 1277-1285. [10.1080/14786419.2016.1242000]
Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy
TOMASSINI, Lamberto;VENDITTI, ALESSANDRO;SERAFINI, Mauro;NICOLETTI, Marcello
2017
Abstract
Four pyrrolizidine alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276–0.769.| File | Dimensione | Formato | |
|---|---|---|---|
|
Benamar_Acetylcholinesterase-inhibitory_2017.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
1.1 MB
Formato
Adobe PDF
|
1.1 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
