Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most potent intervention for infectious disease prevention. Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. The available literature indicates that the immunological response to vaccines in CD children does not differ markedly from that of general population and antibody titres are high enough to provide long-term protection, except for hepatitis B virus vaccine. In this article, we review and discuss the scarce literature in this field in order to provide clinical practice guidelines to achieve the most efficient monitoring of the response to vaccines in pediatric CD patients.

Immune response to vaccines in children with celiac disease / Anania, Caterina; Olivero, Francesca; Spagnolo, Alessandra; Chiesa, Claudio; Pacifico, Lucia. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - STAMPA. - 23:18(2017), pp. 3205-3213. [10.3748/wjg.v23.i18.3205]

Immune response to vaccines in children with celiac disease

ANANIA, Caterina;OLIVERO, FRANCESCA;Spagnolo, Alessandra;CHIESA, CLAUDIO;PACIFICO, Lucia
2017

Abstract

Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most potent intervention for infectious disease prevention. Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. The available literature indicates that the immunological response to vaccines in CD children does not differ markedly from that of general population and antibody titres are high enough to provide long-term protection, except for hepatitis B virus vaccine. In this article, we review and discuss the scarce literature in this field in order to provide clinical practice guidelines to achieve the most efficient monitoring of the response to vaccines in pediatric CD patients.
2017
celiac disease; children; infection; vaccines; hepatitis B vaccine; HLA; gluten free diet
01 Pubblicazione su rivista::01m Editorial/Introduzione in rivista
Immune response to vaccines in children with celiac disease / Anania, Caterina; Olivero, Francesca; Spagnolo, Alessandra; Chiesa, Claudio; Pacifico, Lucia. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - STAMPA. - 23:18(2017), pp. 3205-3213. [10.3748/wjg.v23.i18.3205]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/966516
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