Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness of skeletal and breathing muscles. The aim of the current review is to describe the findings in the existing literature about respiratory and muscle dysfunction in PAH. Animal and clinical studies regarding both respiratory and peripheral skeletal muscles and the effect of exercise training on muscle function in PAH patients are analyzed.

Pulmonary arterial hypertension-related myopathy: an overview of current data and future perspectives / Marra, ALBERTO MARIA; Arcopinto, M; Bossone, E; Ehlken, N; Cittadini, A; Grünig, E.. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 25:2(2015), pp. 131-9-139. [10.1016/j.numecd.2014.10.005]

Pulmonary arterial hypertension-related myopathy: an overview of current data and future perspectives

MARRA, ALBERTO MARIA;
2015

Abstract

Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness of skeletal and breathing muscles. The aim of the current review is to describe the findings in the existing literature about respiratory and muscle dysfunction in PAH. Animal and clinical studies regarding both respiratory and peripheral skeletal muscles and the effect of exercise training on muscle function in PAH patients are analyzed.
2015
Exercise training; Muscle wasting; Pulmonary arterial hypertension; Respiratory muscle; Respiratory training; Skeletal muscle; Animals; Disease Models, Animal; Exercise Tolerance; Humans; Hypertension, Pulmonary; Mitochondria; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Oxygen Consumption; Proteasome Endopeptidase Complex; Quality of Life; Randomized Controlled Trials as Topic; Ubiquitin; Exercise
01 Pubblicazione su rivista::01a Articolo in rivista
Pulmonary arterial hypertension-related myopathy: an overview of current data and future perspectives / Marra, ALBERTO MARIA; Arcopinto, M; Bossone, E; Ehlken, N; Cittadini, A; Grünig, E.. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 25:2(2015), pp. 131-9-139. [10.1016/j.numecd.2014.10.005]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/965238
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