The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique in a chronic pressure-overload cardiac rat model.
SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway / Cittadini, Antonio; Monti, Maria Gaia; Iaccarino, Guido; Castiello, Maria Carmina; Baldi, Alfonso; Bossone, Eduardo; Longobardi, Salvatore; Marra, ALBERTO MARIA; Petrillo, Valentina; Saldamarco, Lavinia; During, Matthew John; Saccà, Luigi; Condorelli, Gianluigi. - In: CARDIOVASCULAR RESEARCH. - ISSN 1755-3245. - 96:3(2012), pp. 381-90-390. [10.1093/cvr/cvs261]
SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway
MARRA, ALBERTO MARIA;CONDORELLI, Gianluigi
2012
Abstract
The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique in a chronic pressure-overload cardiac rat model.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
