The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique in a chronic pressure-overload cardiac rat model.

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway / Cittadini, Antonio; Monti, Maria Gaia; Iaccarino, Guido; Castiello, Maria Carmina; Baldi, Alfonso; Bossone, Eduardo; Longobardi, Salvatore; Marra, ALBERTO MARIA; Petrillo, Valentina; Saldamarco, Lavinia; During, Matthew John; Saccà, Luigi; Condorelli, Gianluigi. - In: CARDIOVASCULAR RESEARCH. - ISSN 1755-3245. - 96:3(2012), pp. 381-90-390. [10.1093/cvr/cvs261]

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway

MARRA, ALBERTO MARIA;CONDORELLI, Gianluigi
2012

Abstract

The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique in a chronic pressure-overload cardiac rat model.
2012
Angiopoietin-2; Animals; Apoptosis; Cytokine Receptor gp130; Dependovirus; Disease Models, Animal; Disease Progression; Genetic Vectors; Heart Failure; Hemodynamics; Hypertrophy, Left Ventricular; Janus Kinase 1; Male; Myocardium; Phosphorylation; RNA, Messenger; Rats; Rats, Wistar; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Time Factors; Ultrasonography; Up-Regulation; Vascular Endothelial Growth Factor A; Ventricular Function, Left; Gene Transfer Techniques; Signal Transduction
01 Pubblicazione su rivista::01a Articolo in rivista
SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway / Cittadini, Antonio; Monti, Maria Gaia; Iaccarino, Guido; Castiello, Maria Carmina; Baldi, Alfonso; Bossone, Eduardo; Longobardi, Salvatore; Marra, ALBERTO MARIA; Petrillo, Valentina; Saldamarco, Lavinia; During, Matthew John; Saccà, Luigi; Condorelli, Gianluigi. - In: CARDIOVASCULAR RESEARCH. - ISSN 1755-3245. - 96:3(2012), pp. 381-90-390. [10.1093/cvr/cvs261]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/964964
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