Recent findings suggest that an imbalance of Th1, Th2 and Treg plays a critical role in the pathogenesis of AD and that CD8+ T cells are required for the development of AD lesions.[1, 2] We studied the phenotype of peripheral blood (PB) circulating and intraepithelial lymphocytes deriving from skin affected by chronic moderate–severe AD, acute reaction induced by an atopy patch test to Dermatophagoides spp (Dmix/APT) and in skin spared by AD.
Atopic dermatitis IL17A- and IFN-γ-producing lymphocytes: Investigation in blood, chronic lesions and APT / Grieco, Teresa; Faina, Valentina; Porzia, Alessandra; Paolino, Giovanni; Morrone, Stefania; Bottoni, Ugo; Calvieri, Stefano; Mainiero, Fabrizio. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - (2017). [10.1111/jdv.14258]
Atopic dermatitis IL17A- and IFN-γ-producing lymphocytes: Investigation in blood, chronic lesions and APT
GRIECO, Teresa;FAINA, VALENTINA;PORZIA, Alessandra;paolino, giovanni;MORRONE, Stefania;BOTTONI, Ugo;CALVIERI, Stefano;MAINIERO, Fabrizio
2017
Abstract
Recent findings suggest that an imbalance of Th1, Th2 and Treg plays a critical role in the pathogenesis of AD and that CD8+ T cells are required for the development of AD lesions.[1, 2] We studied the phenotype of peripheral blood (PB) circulating and intraepithelial lymphocytes deriving from skin affected by chronic moderate–severe AD, acute reaction induced by an atopy patch test to Dermatophagoides spp (Dmix/APT) and in skin spared by AD.| File | Dimensione | Formato | |
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