Aim: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. Methods: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. Results: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). Conclusion: The outcome of neuroblastoma in newborns is excellent. in localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying. (C) 2009 Elsevier Ltd. All rights reserved.
Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry / Anna Rita, Gigliotti; Andrea Di, Cataldo; Stefania, Sorrentino; Stefano, Parodi; Antonino, Rizzo; Piero, Buffa; Claudio, Granata; Angela Rita, Sementa; Anna Maria, Fagnani; Massimo, Provenzi; Arcangelo, Prete; Carmelita, D'Ippolito; Clerico, Anna; Aurora, Castellano; Gian Paolo, Tonini; Massimo, Conte; Alberto, Garaventa; Bruno De, Bernardi. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 45:18(2009), pp. 3220-3227. [10.1016/j.ejca.2009.08.020]
Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry
CLERICO, Anna;
2009
Abstract
Aim: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. Methods: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. Results: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). Conclusion: The outcome of neuroblastoma in newborns is excellent. in localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying. (C) 2009 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
