Aim: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. Methods: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. Results: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). Conclusion: The outcome of neuroblastoma in newborns is excellent. in localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying. (C) 2009 Elsevier Ltd. All rights reserved.

Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry / Anna Rita, Gigliotti; Andrea Di, Cataldo; Stefania, Sorrentino; Stefano, Parodi; Antonino, Rizzo; Piero, Buffa; Claudio, Granata; Angela Rita, Sementa; Anna Maria, Fagnani; Massimo, Provenzi; Arcangelo, Prete; Carmelita, D'Ippolito; Clerico, Anna; Aurora, Castellano; Gian Paolo, Tonini; Massimo, Conte; Alberto, Garaventa; Bruno De, Bernardi. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 45:18(2009), pp. 3220-3227. [10.1016/j.ejca.2009.08.020]

Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry

CLERICO, Anna;
2009

Abstract

Aim: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. Methods: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. Results: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). Conclusion: The outcome of neuroblastoma in newborns is excellent. in localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying. (C) 2009 Elsevier Ltd. All rights reserved.
2009
infant; prenatal diagnosis; neuroblastoma; newborn; mycn gene; stage 4s disease
01 Pubblicazione su rivista::01a Articolo in rivista
Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry / Anna Rita, Gigliotti; Andrea Di, Cataldo; Stefania, Sorrentino; Stefano, Parodi; Antonino, Rizzo; Piero, Buffa; Claudio, Granata; Angela Rita, Sementa; Anna Maria, Fagnani; Massimo, Provenzi; Arcangelo, Prete; Carmelita, D'Ippolito; Clerico, Anna; Aurora, Castellano; Gian Paolo, Tonini; Massimo, Conte; Alberto, Garaventa; Bruno De, Bernardi. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 45:18(2009), pp. 3220-3227. [10.1016/j.ejca.2009.08.020]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/96289
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