The natural steroidal alkaloid cyclopamine has been identified as the first inhibitor of the Hedgehog (Hh) signaling pathway, which is implicated in embryonic development and tumorigenesis, as well as is hyperactivated in cancer stem cells (CSCs). The list of Hh-dependent tumors is steadily growing, and it has been estimated that about 25% of all cancer deaths show signs of aberrant Hh pathway activation. Notably, cyclopamine has been found to exert anticancer activity against several types of human cancer and to inhibit CSCs proliferation, thus highlighting the druggability of the Hh pathway and paving new opportunities in anticancer drug discovery. The aim of the present work is to review the main synthetic strategies to cyclopamine and its derivatives, with particular emphasis on the challenging chemical modifications aimed at improving the biological activity of the molecule.

One hundred faces of cyclopamine / Iovine, Valentina; Mori, Mattia; Calcaterra, Andrea; Berardozzi, Simone; Botta, Bruno. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - ELETTRONICO. - 22:12(2016), pp. 1658-1681. [10.2174/1381612822666160112130157]

One hundred faces of cyclopamine

IOVINE, VALENTINA;MORI, MATTIA
;
CALCATERRA, ANDREA;BERARDOZZI, SIMONE;BOTTA, Bruno
2016

Abstract

The natural steroidal alkaloid cyclopamine has been identified as the first inhibitor of the Hedgehog (Hh) signaling pathway, which is implicated in embryonic development and tumorigenesis, as well as is hyperactivated in cancer stem cells (CSCs). The list of Hh-dependent tumors is steadily growing, and it has been estimated that about 25% of all cancer deaths show signs of aberrant Hh pathway activation. Notably, cyclopamine has been found to exert anticancer activity against several types of human cancer and to inhibit CSCs proliferation, thus highlighting the druggability of the Hh pathway and paving new opportunities in anticancer drug discovery. The aim of the present work is to review the main synthetic strategies to cyclopamine and its derivatives, with particular emphasis on the challenging chemical modifications aimed at improving the biological activity of the molecule.
2016
anticancer; C-nor-D-homosteroid; cyclopamine; hedgehog pathway; organic synthesis; veratrum alkaloids
01 Pubblicazione su rivista::01a Articolo in rivista
One hundred faces of cyclopamine / Iovine, Valentina; Mori, Mattia; Calcaterra, Andrea; Berardozzi, Simone; Botta, Bruno. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - ELETTRONICO. - 22:12(2016), pp. 1658-1681. [10.2174/1381612822666160112130157]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/961955
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