The gut microbiota is composed of over 1200 species of anaerobes and aerobes bacteria along with bacteriophages, viruses and fungal species. Increasing evidence indicates that the intestinal microbiota, beside digestive equilibrium, is also crucial for immunologic, hormonal and metabolic homeostasis. The intestinal microbiota interacts with distant organs by signals which may be part of the bacteria themselves or their metabolites. Dysbiosis has been observed in inflammatory or autoimmune disorders such as multiple sclerosis or type 1 diabetes as well as in obesity and type 2 diabetes. Functional thyroid disorders were associated with bacterial overgrowth and a different microbial composition. Although thyroid metabolism was apparently disregarded, the interference of microbiota on peripheral iodothyronine homeostasis is an intriguing issue. In this review we focused on the interactions of intestinal microbiota with thyroid-related micronutrients and with the metabolic steps of endogenous and exogenous iodothyronines.

"With a little help from my friends" - The role of microbiota in thyroid hormone metabolism and enterohepatic recycling / Virili, Camilla; Centanni, Marco. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - STAMPA. - 458:(2017), pp. 39-43. [10.1016/j.mce.2017.01.053]

"With a little help from my friends" - The role of microbiota in thyroid hormone metabolism and enterohepatic recycling

VIRILI, CAMILLA
;
CENTANNI, Marco
2017

Abstract

The gut microbiota is composed of over 1200 species of anaerobes and aerobes bacteria along with bacteriophages, viruses and fungal species. Increasing evidence indicates that the intestinal microbiota, beside digestive equilibrium, is also crucial for immunologic, hormonal and metabolic homeostasis. The intestinal microbiota interacts with distant organs by signals which may be part of the bacteria themselves or their metabolites. Dysbiosis has been observed in inflammatory or autoimmune disorders such as multiple sclerosis or type 1 diabetes as well as in obesity and type 2 diabetes. Functional thyroid disorders were associated with bacterial overgrowth and a different microbial composition. Although thyroid metabolism was apparently disregarded, the interference of microbiota on peripheral iodothyronine homeostasis is an intriguing issue. In this review we focused on the interactions of intestinal microbiota with thyroid-related micronutrients and with the metabolic steps of endogenous and exogenous iodothyronines.
2017
enterohepatic circulation; Iodothyronines metabolism; levothyroxine; microbiota; selenium; thyroxine malabsorption
01 Pubblicazione su rivista::01a Articolo in rivista
"With a little help from my friends" - The role of microbiota in thyroid hormone metabolism and enterohepatic recycling / Virili, Camilla; Centanni, Marco. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - STAMPA. - 458:(2017), pp. 39-43. [10.1016/j.mce.2017.01.053]
File allegati a questo prodotto
File Dimensione Formato  
Virili_Role-microbiota_2017.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 481.09 kB
Formato Adobe PDF
481.09 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/961172
Citazioni
  • ???jsp.display-item.citation.pmc??? 39
  • Scopus 75
  • ???jsp.display-item.citation.isi??? 66
social impact