Aging is associated with impairment of endothelial nitric oxide synthase (eNOS) and progressive reduction in endothelial function. A genetic study on long-living individuals - who are characterized by delays in aging and in the onset of cardiovascular disease - previously revealed I229V ( rs2070325 ) in BPIFB4 as a longevity-associated variant (LAV); the LAV protein enhanced endothelial NO production and vasorelaxation through a PERK/14-3-3/HSP90 signal. Here, we further characterize the molecular mechanisms underlying LAV-BPIFB4-dependent enhancement of vascular function.
LAV-BPIFB4 isoform modulates eNOS signaling through Ca2+/PKC-alpha dependent mechanism / Spinelli, Chiara Carmela; Carrizzo, Albino; Ferrario, Anna; Villa, Francesco; Damato, Antonio; Ambrosio, Mariateresa; Madonna, Michele; Frati, Giacomo; Fucile, Sergio; Sciaccaluga, Miriam; Capunzo, Mario; Calì, Gaetano; Milanesi, Luciano; Maciag, Anna; Puca, Annibale Alessandro; Vecchione, Carmine. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - STAMPA. - 113:7(2017), pp. 795-804. [10.1093/cvr/cvx072]
LAV-BPIFB4 isoform modulates eNOS signaling through Ca2+/PKC-alpha dependent mechanism
FRATI, GIACOMO;FUCILE, Sergio;
2017
Abstract
Aging is associated with impairment of endothelial nitric oxide synthase (eNOS) and progressive reduction in endothelial function. A genetic study on long-living individuals - who are characterized by delays in aging and in the onset of cardiovascular disease - previously revealed I229V ( rs2070325 ) in BPIFB4 as a longevity-associated variant (LAV); the LAV protein enhanced endothelial NO production and vasorelaxation through a PERK/14-3-3/HSP90 signal. Here, we further characterize the molecular mechanisms underlying LAV-BPIFB4-dependent enhancement of vascular function.| File | Dimensione | Formato | |
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