Benign prostatic hyperplasia (BPH) is the most common urological disease in elderly men. Epidemiological data suggest a causal link between this condition and prostatic inflammation. The prostate is an immune-competent organ characterized by the presence of a complex immune system. Several stimuli, including infectious agents, urinary reflux, metabolic syndrome, the ageing process, and autoimmune response, have been described as triggers for the dysregulation of the prostatic immune system via different molecular pathways involving the development of inflammatory infiltrates. From a pathophysiological standpoint, subsequent tissue damage and chronic tissue healing could result in the development of BPH nodules.

Inflammatory mediators in the development and progression of benign prostatic hyperplasia / DE NUNZIO, Cosimo; Presicce, Fabrizio; Tubaro, Andrea. - In: NATURE REVIEWS. UROLOGY. - ISSN 1759-4812. - 13:10(2016), pp. 613-626. [10.1038/nrurol.2016.168]

Inflammatory mediators in the development and progression of benign prostatic hyperplasia

DE NUNZIO, Cosimo
;
PRESICCE, FABRIZIO;TUBARO, ANDREA
2016

Abstract

Benign prostatic hyperplasia (BPH) is the most common urological disease in elderly men. Epidemiological data suggest a causal link between this condition and prostatic inflammation. The prostate is an immune-competent organ characterized by the presence of a complex immune system. Several stimuli, including infectious agents, urinary reflux, metabolic syndrome, the ageing process, and autoimmune response, have been described as triggers for the dysregulation of the prostatic immune system via different molecular pathways involving the development of inflammatory infiltrates. From a pathophysiological standpoint, subsequent tissue damage and chronic tissue healing could result in the development of BPH nodules.
2016
urology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Inflammatory mediators in the development and progression of benign prostatic hyperplasia / DE NUNZIO, Cosimo; Presicce, Fabrizio; Tubaro, Andrea. - In: NATURE REVIEWS. UROLOGY. - ISSN 1759-4812. - 13:10(2016), pp. 613-626. [10.1038/nrurol.2016.168]
File allegati a questo prodotto
File Dimensione Formato  
DeNunzio_Inflammatory-mediators_2016.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.42 MB
Formato Adobe PDF
2.42 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/957465
Citazioni
  • ???jsp.display-item.citation.pmc??? 69
  • Scopus 166
  • ???jsp.display-item.citation.isi??? 153
social impact