Quantitative, non-invasive and local measurements of arterial mechanical properties could be highly beneficial for early diagnosis of cardiovascular disease and follow up of treatment. Arterial shear wave elastography (SWE) and wave velocity dispersion analysis have previously been applied to measure arterial stiffness. Arterial wall thickness (h) and inner diameter (D) vary with age and pathology and may influence the shear wave propagation. Nevertheless, the effect of arterial geometry in SWE has not yet been systematically investigated. In this study the influence of geometry on the estimated mechanical properties of plates (h = 0.5–3 mm) and hollow cylinders (h = 1, 2 and 3 mm, D = 6 mm) was assessed by experiments in phantoms and by finite element method simulations. In addition, simulations in hollow cylinders with wall thickness difficult to achieve in phantoms were performed (h = 0.5–1.3 mm, D = 5–8 mm). The phase velocity curves obtained from experiments and simulations were compared in the frequency range 200–1000 Hz and showed good agreement (R2 = 0.80 ± 0.07 for plates and R2 = 0.82 ± 0.04 for hollow cylinders). Wall thickness had a larger effect than diameter on the dispersion curves, which did not have major effects above 400 Hz. An underestimation of 0.1–0.2 mm in wall thickness introduces an error 4–9 kPa in hollow cylinders with shear modulus of 21–26 kPa. Therefore, wall thickness should correctly be measured in arterial SWE applications for accurate mechanical properties estimation.

Influence of wall thickness and diameter on arterial shear wave elastography: a phantom and finite element study / Maksuti, Elira; Bini, Fabiano; Fiorentini, Stefano; Blasi, Giulia; Urban, Matthew W.; Marinozzi, Franco; Larsson, Matilda. - In: PHYSICS IN MEDICINE AND BIOLOGY. - ISSN 0031-9155. - ELETTRONICO. - 62:7(2017), pp. 2694-2718. [10.1088/1361-6560/aa591d]

Influence of wall thickness and diameter on arterial shear wave elastography: a phantom and finite element study

BINI, FABIANO;MARINOZZI, Franco;
2017

Abstract

Quantitative, non-invasive and local measurements of arterial mechanical properties could be highly beneficial for early diagnosis of cardiovascular disease and follow up of treatment. Arterial shear wave elastography (SWE) and wave velocity dispersion analysis have previously been applied to measure arterial stiffness. Arterial wall thickness (h) and inner diameter (D) vary with age and pathology and may influence the shear wave propagation. Nevertheless, the effect of arterial geometry in SWE has not yet been systematically investigated. In this study the influence of geometry on the estimated mechanical properties of plates (h = 0.5–3 mm) and hollow cylinders (h = 1, 2 and 3 mm, D = 6 mm) was assessed by experiments in phantoms and by finite element method simulations. In addition, simulations in hollow cylinders with wall thickness difficult to achieve in phantoms were performed (h = 0.5–1.3 mm, D = 5–8 mm). The phase velocity curves obtained from experiments and simulations were compared in the frequency range 200–1000 Hz and showed good agreement (R2 = 0.80 ± 0.07 for plates and R2 = 0.82 ± 0.04 for hollow cylinders). Wall thickness had a larger effect than diameter on the dispersion curves, which did not have major effects above 400 Hz. An underestimation of 0.1–0.2 mm in wall thickness introduces an error 4–9 kPa in hollow cylinders with shear modulus of 21–26 kPa. Therefore, wall thickness should correctly be measured in arterial SWE applications for accurate mechanical properties estimation.
2017
arterial geometry; arterial stiffness; finite element method; phantom; phase velocity; wall thickness; shear wave elastography
01 Pubblicazione su rivista::01a Articolo in rivista
Influence of wall thickness and diameter on arterial shear wave elastography: a phantom and finite element study / Maksuti, Elira; Bini, Fabiano; Fiorentini, Stefano; Blasi, Giulia; Urban, Matthew W.; Marinozzi, Franco; Larsson, Matilda. - In: PHYSICS IN MEDICINE AND BIOLOGY. - ISSN 0031-9155. - ELETTRONICO. - 62:7(2017), pp. 2694-2718. [10.1088/1361-6560/aa591d]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/957345
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