This minireview surveys the work of our research group directed toward finding novel antimycobacterial and anti-inflammatory drugs. Many active compounds were found with a common 1,5-diarylpyrrole skeleton. Some of the synthesized compounds, designed on the basis of structure–activity relationship studies, showed very interesting activities and proved to be effective in vivo, thus providing evidence of their attractiveness for lead optimization.

1,5-Diarylpyrroles as potent antitubercular and anti-inflammatory agents / Venditti, Giulia; Poce, Giovanna; Consalvi, Sara; Biava, Mariangela. - In: CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - ISSN 0009-3122. - STAMPA. - 53:3(2017), pp. 281-291. [10.1007/s10593-017-2050-8]

1,5-Diarylpyrroles as potent antitubercular and anti-inflammatory agents

VENDITTI, GIULIA;POCE, Giovanna;CONSALVI, SARA
;
BIAVA, Mariangela
2017

Abstract

This minireview surveys the work of our research group directed toward finding novel antimycobacterial and anti-inflammatory drugs. Many active compounds were found with a common 1,5-diarylpyrrole skeleton. Some of the synthesized compounds, designed on the basis of structure–activity relationship studies, showed very interesting activities and proved to be effective in vivo, thus providing evidence of their attractiveness for lead optimization.
2017
anti-inflammatory agents; antimycobacterial agents; COX-2 selective inhibitors; nitrogen oxide donors; pyrroles; tuberculosis; organic chemistry
01 Pubblicazione su rivista::01a Articolo in rivista
1,5-Diarylpyrroles as potent antitubercular and anti-inflammatory agents / Venditti, Giulia; Poce, Giovanna; Consalvi, Sara; Biava, Mariangela. - In: CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - ISSN 0009-3122. - STAMPA. - 53:3(2017), pp. 281-291. [10.1007/s10593-017-2050-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/957084
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