Singly aquated and diaquated species are key intermediates in the mechanism responsible for the antitumor activity of cisplatin. Aqua complexes [PtX(NH3)2(H2O)]+ (X ¼ Cl, OH), obtained in water by hydrolysis of cisplatin and of the inactive isomer transplatin, are transferred into the gas-phase by electrospray ionization. The so-formed ions, cis- and trans-[PtX(NH3)2(H2O)]+, have been allowed to react with selected ligands, representing platination targets in the biological environment. The reaction kinetics monitored in the gas-phase show consistently higher reactivity for the chloro complexes, [PtCl(NH3)2(H2O)]+, with respect to the hydroxo counterparts, [Pt(OH)(NH3)2(H2O)]+. The latter species, both cis- and trans-isomers, have been assayed by IRMPD spectroscopy in the NH/OH stretching region and their vibrational and geometric features are compared with the ones pertaining to the already described chloro complexes, cis- and trans-[PtCl(NH3)2(H2O)]+.

Hydrolysis of cis- and transplatin: structure and reactivity of the aqua complexes in a solvent free environment / Corinti, Davide; Coletti, Cecilia; Re, Nazzareno; Piccirillo, Susanna; Giampà, Marco; Crestoni, Maria Elisa; Fornarini, Simonetta. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 7:26(2017), pp. 15877-15884. [10.1039/C7RA01182B]

Hydrolysis of cis- and transplatin: structure and reactivity of the aqua complexes in a solvent free environment

CORINTI, DAVIDE;CRESTONI, Maria Elisa;FORNARINI, Simonetta
2017

Abstract

Singly aquated and diaquated species are key intermediates in the mechanism responsible for the antitumor activity of cisplatin. Aqua complexes [PtX(NH3)2(H2O)]+ (X ¼ Cl, OH), obtained in water by hydrolysis of cisplatin and of the inactive isomer transplatin, are transferred into the gas-phase by electrospray ionization. The so-formed ions, cis- and trans-[PtX(NH3)2(H2O)]+, have been allowed to react with selected ligands, representing platination targets in the biological environment. The reaction kinetics monitored in the gas-phase show consistently higher reactivity for the chloro complexes, [PtCl(NH3)2(H2O)]+, with respect to the hydroxo counterparts, [Pt(OH)(NH3)2(H2O)]+. The latter species, both cis- and trans-isomers, have been assayed by IRMPD spectroscopy in the NH/OH stretching region and their vibrational and geometric features are compared with the ones pertaining to the already described chloro complexes, cis- and trans-[PtCl(NH3)2(H2O)]+.
chemistry (all); chemical engineering (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Hydrolysis of cis- and transplatin: structure and reactivity of the aqua complexes in a solvent free environment / Corinti, Davide; Coletti, Cecilia; Re, Nazzareno; Piccirillo, Susanna; Giampà, Marco; Crestoni, Maria Elisa; Fornarini, Simonetta. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 7:26(2017), pp. 15877-15884. [10.1039/C7RA01182B]
File allegati a questo prodotto
File Dimensione Formato  
Corinti_Hydrolysis_2017.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 436.53 kB
Formato Adobe PDF
436.53 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/956662
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 33
social impact