INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases resulting in neurological impairment at any age from newborn to adulthood. METHODS AND RESULTS: The International Working Group on Neurotransmitter related Disorders (iNTD) is the first international network focusing on the study of primary and secondary neurotransmitter disorders. It was founded with the aim to foster exchange and improve knowledge in the field of these rare diseases. The newly established iNTD patient registry for neurotransmitter related diseases collects longitudinal data on the natural disease course, approach to diagnosis, therapeutic strategies, and quality of life of affected patients. The registry forms the evidence base for the development of consensus guidelines for patients with neurotransmitter related disorders. CONCLUSION: The iNTD network and registry will improve knowledge and strengthen research capacities in the field of inborn neurotransmitter disorders. The evidence-based guidelines will facilitate standardized diagnostic procedures and treatment approaches.

The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders / Opladen, Thomas; Cortès Saladelafont, Elisenda; Mastrangelo, Mario; Horvath, Gabriella; Pons, Roser; Lopez Laso, Eduardo; Fernández Ramos, Joaquín A.; Honzik, Tomas; Pearson, Toni; Friedman, Jennifer; Scholl Bürgi, Sabine; Wassenberg, Tessa; Jung Klawitter, Sabine; Kuseyri, Oya; Jeltsch, Kathrin; Kurian, Manju A.; Garcia Cazorla, Àngels. - In: MOLECULAR GENETICS AND METABOLISM REPORTS. - ISSN 2214-4269. - ELETTRONICO. - 9:(2016), pp. 61-66. [10.1016/j.ymgmr.2016.09.006]

The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders

MASTRANGELO, Mario;
2016

Abstract

INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases resulting in neurological impairment at any age from newborn to adulthood. METHODS AND RESULTS: The International Working Group on Neurotransmitter related Disorders (iNTD) is the first international network focusing on the study of primary and secondary neurotransmitter disorders. It was founded with the aim to foster exchange and improve knowledge in the field of these rare diseases. The newly established iNTD patient registry for neurotransmitter related diseases collects longitudinal data on the natural disease course, approach to diagnosis, therapeutic strategies, and quality of life of affected patients. The registry forms the evidence base for the development of consensus guidelines for patients with neurotransmitter related disorders. CONCLUSION: The iNTD network and registry will improve knowledge and strengthen research capacities in the field of inborn neurotransmitter disorders. The evidence-based guidelines will facilitate standardized diagnostic procedures and treatment approaches.
2016
database; dopamine; GABA; glycine; guideline; network; neurotransmitter; patient registry; serine; serotonin; molecular biology; genetics; endocrinology
01 Pubblicazione su rivista::01a Articolo in rivista
The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders / Opladen, Thomas; Cortès Saladelafont, Elisenda; Mastrangelo, Mario; Horvath, Gabriella; Pons, Roser; Lopez Laso, Eduardo; Fernández Ramos, Joaquín A.; Honzik, Tomas; Pearson, Toni; Friedman, Jennifer; Scholl Bürgi, Sabine; Wassenberg, Tessa; Jung Klawitter, Sabine; Kuseyri, Oya; Jeltsch, Kathrin; Kurian, Manju A.; Garcia Cazorla, Àngels. - In: MOLECULAR GENETICS AND METABOLISM REPORTS. - ISSN 2214-4269. - ELETTRONICO. - 9:(2016), pp. 61-66. [10.1016/j.ymgmr.2016.09.006]
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