Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of 66%. 3-aminopropylphosphinic acid was prepared from allylamine in three steps with an overall yield of 56%. These improved protocols allowed to obtain these commercially unavailable phosphinic analogues of glutamic acid and GABA for testing on potential molecular targets.
Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids / Khomutov, M. A.; Formanovsky, A. A.; Mikhura, I. V.; Vepsalainen, J.; Kochetkov, S. N.; DE BIASE, Daniela; Khomutov, A. R.. - In: RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY. - ISSN 1068-1620. - STAMPA. - 42:6(2016), pp. 672-676. [10.1134/S1068162016060042]
Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids
DE BIASE, Daniela
;
2016
Abstract
Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of 66%. 3-aminopropylphosphinic acid was prepared from allylamine in three steps with an overall yield of 56%. These improved protocols allowed to obtain these commercially unavailable phosphinic analogues of glutamic acid and GABA for testing on potential molecular targets.| File | Dimensione | Formato | |
|---|---|---|---|
|
Khomutov_Convenient-syntheses_2016.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
166.41 kB
Formato
Adobe PDF
|
166.41 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
