Escherichia coli has a remarkable ability to survive low pH and possesses a number of different genetic systems that enable it to do this. These may be expressed constitutively, typically in stationary phase, or induced by growth under a variety of conditions. The activities of these systems have been implicated in the ability of E. coli to pass the acidic barrier of the stomach and to become established in the gastrointestinal tract, something causing serious infections. However, much of the work characterizing these systems has been done on standard laboratory strains of E. coli and under conditions which do not closely resemble those found in the human gut. Here we review what is known about acid resistance in E. coli as a model laboratory organism and in the context of its lifestyle as an inhabitant - sometimes an unwelcome - one of the human gut.

The Escherichia coli acid stress response and its significance for pathogenesis / DE BIASE, Daniela; Lund, Peter A.. - In: ADVANCES IN APPLIED MICROBIOLOGY. - ISSN 0065-2164. - 92:(2015), pp. 49-88. [10.1016/bs.aambs.2015.03.002]

The Escherichia coli acid stress response and its significance for pathogenesis

DE BIASE, Daniela;
2015

Abstract

Escherichia coli has a remarkable ability to survive low pH and possesses a number of different genetic systems that enable it to do this. These may be expressed constitutively, typically in stationary phase, or induced by growth under a variety of conditions. The activities of these systems have been implicated in the ability of E. coli to pass the acidic barrier of the stomach and to become established in the gastrointestinal tract, something causing serious infections. However, much of the work characterizing these systems has been done on standard laboratory strains of E. coli and under conditions which do not closely resemble those found in the human gut. Here we review what is known about acid resistance in E. coli as a model laboratory organism and in the context of its lifestyle as an inhabitant - sometimes an unwelcome - one of the human gut.
2015
acid; acid resistance; amino acid decarboxylase; Escherichia coli; pathogenesis; two component systems; acids; animals; Escherichia coli; Escherichia coli Infections; Escherichia coli proteins; humans; hydrogen-ion concentration; applied microbiology and biotechnology; medicine (all)
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The Escherichia coli acid stress response and its significance for pathogenesis / DE BIASE, Daniela; Lund, Peter A.. - In: ADVANCES IN APPLIED MICROBIOLOGY. - ISSN 0065-2164. - 92:(2015), pp. 49-88. [10.1016/bs.aambs.2015.03.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/954765
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