Objective: We investigated whether ADHD children who are positive to Purkinje cell antibodies display pro-inflammatory activity associated with high cytokine serum levels. Method: Fifty-eight ADHD outpatients were compared with 36 healthy, age- and sex-matched children. Forty-five of the ADHD children were positive to anti-Yo antibodies, whereas 34 of the control children were negative. Interleukin 4 (IL-4), IL-6, IL-10, IL-17, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) cytokine serum levels were tested in ADHD children who were positive to anti-Yo antibodies and in the control children who were negative. Results: Anti-Yo antibodies were present to a greater extent in the ADHD group: 77.58% versus 22.42%. Significant differences emerged between the two groups in IL-6 and IL-10, with higher cytokine levels being detected in ADHD children than in controls. Conclusion: Immune processes in ADHD are likely to be associated with mediators of inflammation, such as cytokines. These results contribute to our understanding of action of neural antibodies and cytokines in ADHD.

Anti-yo antibodies in children with attention deficit hyperactivity disorder. first results about serum cytokines / Donfrancesco, R.; Nativio, Paola; Di Benedetto, A.; Villa, MARIA PIA; Andriola, E.; Melegari, M. G.; Cipriano, E.; DI TRANI, Michela. - In: JOURNAL OF ATTENTION DISORDERS. - ISSN 1087-0547. - STAMPA. - 11:24(2020), pp. 1497-1502. [0.1177/1087054716643387]

Anti-yo antibodies in children with attention deficit hyperactivity disorder. first results about serum cytokines

NATIVIO, PAOLA;VILLA, MARIA PIA;Cipriano, E.;DI TRANI, MICHELA
2020

Abstract

Objective: We investigated whether ADHD children who are positive to Purkinje cell antibodies display pro-inflammatory activity associated with high cytokine serum levels. Method: Fifty-eight ADHD outpatients were compared with 36 healthy, age- and sex-matched children. Forty-five of the ADHD children were positive to anti-Yo antibodies, whereas 34 of the control children were negative. Interleukin 4 (IL-4), IL-6, IL-10, IL-17, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) cytokine serum levels were tested in ADHD children who were positive to anti-Yo antibodies and in the control children who were negative. Results: Anti-Yo antibodies were present to a greater extent in the ADHD group: 77.58% versus 22.42%. Significant differences emerged between the two groups in IL-6 and IL-10, with higher cytokine levels being detected in ADHD children than in controls. Conclusion: Immune processes in ADHD are likely to be associated with mediators of inflammation, such as cytokines. These results contribute to our understanding of action of neural antibodies and cytokines in ADHD.
cytokines, ADHD; anti-Yo; IL-6; IL-10
01 Pubblicazione su rivista::01a Articolo in rivista
Anti-yo antibodies in children with attention deficit hyperactivity disorder. first results about serum cytokines / Donfrancesco, R.; Nativio, Paola; Di Benedetto, A.; Villa, MARIA PIA; Andriola, E.; Melegari, M. G.; Cipriano, E.; DI TRANI, Michela. - In: JOURNAL OF ATTENTION DISORDERS. - ISSN 1087-0547. - STAMPA. - 11:24(2020), pp. 1497-1502. [0.1177/1087054716643387]
File allegati a questo prodotto
File Dimensione Formato  
Donfrancesco_Anti-Yo-antibodies_2020.pdf

solo gestori archivio

Note: Articolo principale
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 254.98 kB
Formato Adobe PDF
254.98 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/954561
Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 33
social impact