Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We previously identified a set of microRNA (miRNAs) differentially expressed in TETs and normal thymic tissues and among the most significantly deregulated we described the down-regulation of miR-145-5p in TET. Here we describe the mRNAs diversely regulated in TETs and analyze the correlation between these and the miRNAs previously identified, focusing in particular on miR-145-5p. Then, we examine the functional role of miR-145-5p in TETs and its epigenetic transcriptional regulation.
Thymic epithelial tumors phenotype relies on miR-145-5p epigenetic regulation / Bellissimo, Teresa; Ganci, Federica; Gallo, Enzo; Sacconi, Andrea; Tito, Claudia; DE ANGELIS, Luciana; Pulito, Claudio; Masciarelli, Silvia; Diso, Daniele; Anile, Marco; Petrozza, Vincenzo; Giangaspero, Felice; Pescarmona, Edoardo; Facciolo, Francesco; Venuta, Federico; Marino, Mirella; Blandino, Giovanni; Fazi, Francesco. - In: MOLECULAR CANCER. - ISSN 1476-4598. - STAMPA. - 16:1(2017), pp. 1-15. [10.1186/s12943-017-0655-2]
Thymic epithelial tumors phenotype relies on miR-145-5p epigenetic regulation
BELLISSIMO, TERESA;TITO, CLAUDIA;DE ANGELIS, Luciana;PULITO, CLAUDIO;MASCIARELLI, SILVIA;DISO, DANIELE;ANILE, MARCO;PETROZZA, Vincenzo;GIANGASPERO, FELICE;VENUTA, Federico;FAZI, Francesco
2017
Abstract
Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We previously identified a set of microRNA (miRNAs) differentially expressed in TETs and normal thymic tissues and among the most significantly deregulated we described the down-regulation of miR-145-5p in TET. Here we describe the mRNAs diversely regulated in TETs and analyze the correlation between these and the miRNAs previously identified, focusing in particular on miR-145-5p. Then, we examine the functional role of miR-145-5p in TETs and its epigenetic transcriptional regulation.| File | Dimensione | Formato | |
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