Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has been described only more recently. The ocular surface is a morphofunctional unit comprising eyelid margin, tear film, cornea, and conjunctiva. Increasing evidence indicates that these structures are under a sex hormone control and relevant diseases such as ocular allergy and dry eye are often caused by alterations in circulating or local steroid hormones levels. Novel treatments targeting sex hormone receptors on ocular surface epithelial cells are also being developed. In this review we aim to describe the current knowledge on the effects of sex hormones at the ocular surface, with a special focus on the effects of androgen imbalance in PCOS.

Effects of sex hormones on ocular surface epithelia: lessons learned from polycystic ovary syndrome / Mantelli, Flavio; Moretti, Costanzo; Macchi, Ilaria; Massaro Giordano, Giacomina; Cozzupoli, Grazia Maria; Lambiase, Alessandro; Bonini, Stefano. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - STAMPA. - 231:5(2016), pp. 971-975. [10.1002/jcp.25221]

Effects of sex hormones on ocular surface epithelia: lessons learned from polycystic ovary syndrome

LAMBIASE, ALESSANDRO;
2016

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women of reproductive age. Although its clinical consequences have been known for a long time to extend beyond the reproductive system, with type-2 diabetes and obesity being the most common, the involvement of the ocular surface in PCOS has been described only more recently. The ocular surface is a morphofunctional unit comprising eyelid margin, tear film, cornea, and conjunctiva. Increasing evidence indicates that these structures are under a sex hormone control and relevant diseases such as ocular allergy and dry eye are often caused by alterations in circulating or local steroid hormones levels. Novel treatments targeting sex hormone receptors on ocular surface epithelial cells are also being developed. In this review we aim to describe the current knowledge on the effects of sex hormones at the ocular surface, with a special focus on the effects of androgen imbalance in PCOS.
2016
tear function; gonadal steroid hormones; humans; polycystic ovary syndrome; ocular surface; cornea; lacrimal gland
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Effects of sex hormones on ocular surface epithelia: lessons learned from polycystic ovary syndrome / Mantelli, Flavio; Moretti, Costanzo; Macchi, Ilaria; Massaro Giordano, Giacomina; Cozzupoli, Grazia Maria; Lambiase, Alessandro; Bonini, Stefano. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - STAMPA. - 231:5(2016), pp. 971-975. [10.1002/jcp.25221]
File allegati a questo prodotto
File Dimensione Formato  
Mantelli_Effects of Sex_2016.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 105.13 kB
Formato Adobe PDF
105.13 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/954340
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 21
social impact