Research underlines that intergenerational transmission of psychopathological risk results from a complex interplay of genetic and environmental risk factors which predispose child to develop emotionalbehavioral problems. Mechanisms of transmission are poorly understood, but few studies have focused on the role played by dopamine transporter (DAT) gene. This review aims to examine mediating mechanism of DAT genotype-environmental interaction (GxE), DAT genotype-environmental correlation (rGE), and methylation status involved in transmission of psychopathological risk. The review of literature was made through researches in university libraries on paper material, and telematics systems research. Studies have evidenced that DAT is implicated in intergenerational transmission of psychopathological risk. Results are mixed regarding its genetic variants, but mechanisms through which this gene can affect both quality of parenting and child development are partially established. Only few studies have examined methylation mechanisms that can be implicated. Findings suggest to involve an improved focus on DAT genotypes, methylation status associated, and their relationship with environment to better understanding child’s vulnerability and resilience following exposure to contextual risk factors associated with parental psychopathological symptoms.
Dopamine transporter and transmission of psychopathological risk. A review of gene-environment interplay / Cimino, Silvia; Marzilli, Eleonora; Ballarotto, Giulia; Cerniglia, Luca; Walter, Adriani; Pascale, Esterina. - In: THE EUROPEAN PROCEEDINGS OF SOCIAL & BEHAVIOURAL SCIENCES. - ISSN 2357-1330. - STAMPA. - 30:(2017), pp. 58-68. (Intervento presentato al convegno 3rd International Conference on Health and Health Psychology tenutosi a Porto; Portugal) [10.15405/epsbs.2017.09.6].
Dopamine transporter and transmission of psychopathological risk. A review of gene-environment interplay
CIMINO, SILVIA;Eleonora Marzilli;Giulia Ballarotto;Luca Cerniglia;Esterina Pascale
2017
Abstract
Research underlines that intergenerational transmission of psychopathological risk results from a complex interplay of genetic and environmental risk factors which predispose child to develop emotionalbehavioral problems. Mechanisms of transmission are poorly understood, but few studies have focused on the role played by dopamine transporter (DAT) gene. This review aims to examine mediating mechanism of DAT genotype-environmental interaction (GxE), DAT genotype-environmental correlation (rGE), and methylation status involved in transmission of psychopathological risk. The review of literature was made through researches in university libraries on paper material, and telematics systems research. Studies have evidenced that DAT is implicated in intergenerational transmission of psychopathological risk. Results are mixed regarding its genetic variants, but mechanisms through which this gene can affect both quality of parenting and child development are partially established. Only few studies have examined methylation mechanisms that can be implicated. Findings suggest to involve an improved focus on DAT genotypes, methylation status associated, and their relationship with environment to better understanding child’s vulnerability and resilience following exposure to contextual risk factors associated with parental psychopathological symptoms.File | Dimensione | Formato | |
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