Health care workers (HCW) are particularly at risk of acquiring tuberculosis (TB), even in countries with low TB incidence. Therefore, TB screening in HCW is a useful prevention strategy in countries with both low and high TB incidence. Tuberculin skin test (TST) is widely used although it suffers of low specificity; on the contrary, the in vitro enzyme immunoassay tests (IGRA) show superior specificity and sensitivity but are more expensive. The present study reports the results of a three-year TB surveillance among HCW in a large teaching hospital in Rome, using TST (by standard Mantoux technique) and IGRA (by QuantiFERON-TB) as first- and second-level screening tests, respectively. Out of 2290 HCW enrolled, 141 (6.1%) had a positive TST; among them, 99 (70.2%) underwent the IGRA and 16 tested positive (16.1%). The frequency of HCW tested positive for TB seems not far from other experiences in low incidence countries. Our results confirm the higher specificity of IGRA, but, due to its higher cost, TST can be considered a good first level screening test, whose positive results should be further confirmed by IGRA before the patients undergo X-ray diagnosis and/or chemotherapy.

Screening for Tuberculosis in Health Care Workers. Experience in an Italian Teaching Hospital / Napoli, Christian; Ferretti, Filippo; DI NINNO, Filippo; Orioli, Riccardo; Marani, Alessandra; Sarlo, MARIA GIUDITTA; Prestigiacomo, Claudio; De Luca, Assunta; Orsi, Giovanni Battista. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - ELETTRONICO. - 2017:(2017), pp. 1-7. [10.1155/2017/7538037]

Screening for Tuberculosis in Health Care Workers. Experience in an Italian Teaching Hospital

NAPOLI, CHRISTIAN;FERRETTI, FILIPPO;DI NINNO, FILIPPO;orioli, riccardo;MARANI, ALESSANDRA;SARLO, MARIA GIUDITTA;PRESTIGIACOMO, Claudio;ORSI, Giovanni Battista
2017

Abstract

Health care workers (HCW) are particularly at risk of acquiring tuberculosis (TB), even in countries with low TB incidence. Therefore, TB screening in HCW is a useful prevention strategy in countries with both low and high TB incidence. Tuberculin skin test (TST) is widely used although it suffers of low specificity; on the contrary, the in vitro enzyme immunoassay tests (IGRA) show superior specificity and sensitivity but are more expensive. The present study reports the results of a three-year TB surveillance among HCW in a large teaching hospital in Rome, using TST (by standard Mantoux technique) and IGRA (by QuantiFERON-TB) as first- and second-level screening tests, respectively. Out of 2290 HCW enrolled, 141 (6.1%) had a positive TST; among them, 99 (70.2%) underwent the IGRA and 16 tested positive (16.1%). The frequency of HCW tested positive for TB seems not far from other experiences in low incidence countries. Our results confirm the higher specificity of IGRA, but, due to its higher cost, TST can be considered a good first level screening test, whose positive results should be further confirmed by IGRA before the patients undergo X-ray diagnosis and/or chemotherapy.
2017
tuberculosis; surveillance; healthcare workers;
01 Pubblicazione su rivista::01a Articolo in rivista
Screening for Tuberculosis in Health Care Workers. Experience in an Italian Teaching Hospital / Napoli, Christian; Ferretti, Filippo; DI NINNO, Filippo; Orioli, Riccardo; Marani, Alessandra; Sarlo, MARIA GIUDITTA; Prestigiacomo, Claudio; De Luca, Assunta; Orsi, Giovanni Battista. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - ELETTRONICO. - 2017:(2017), pp. 1-7. [10.1155/2017/7538037]
File allegati a questo prodotto
File Dimensione Formato  
Napoli_Screening_2017.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.29 MB
Formato Adobe PDF
1.29 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/953454
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 17
social impact