Perinatal exposure to omega-3 fatty acid imbalance leads to enduring memory alterations in rats Colucci Paola1; De Castro Valentina1; Peloso Andrea1; Campolongo Patrizia1 1Department of Physiology and Pharmacology. Sapienza University of Rome. Rome. Italy Growing evidence shows that long-chain omega-3 fatty acids are crucially involved in brain development and function. Omega-3 fatty acids are extensively added in large amount to several food products and particularly in newborn and infant aliments. Preclinical data show that chronic dietary omega-3 fatty acid deficiency induces behavioral alterations in rodents. Only few studies, instead, have examined the effects of omega-3 fatty acids supplementation on cognitive performances. Therefore, the aim of the present study was to investigate whether chronic dietary omega-3 deprivation or supplementation, during perinatal period, adolescence and adulthood, could affect brain development and function with emphasis on cognitive and emotional processes. The offspring of Sprague Dawley rats, fed with a omega-3 enriched or omega-3 deficient diet throughout mating, pregnancy and lactation, were subjected to a isolation-induced ultrasonic vocalization (USV) emission test and their emissions were compared with calls emitted by normal-nourished pups (control group fed with a diet with balanced omega-3 omega-6 ratio). At PND13, pups from the three exposure groups were tested in the homing test. Adolescent and adult offspring were subjected to the open-field test, elevated plus maze, inhibitory avoidance, and object recognition tests. Significant differences between rats fed with omega-3 enriched or omega-3 deficient diet and the control group were found in USV emission, elevated plus maze and object recognition tests. The present findings suggest that not only a deficiency but also a supplementation of omega-3 fatty acids could induce detrimental effects on brain development leading to enduring behavioral alterations.
Perinatal exposure to omega-3 fatty acid imbalance leads to enduring memory alterations in rats / Colucci, Paola; DE CASTRO, Valentina; Peloso, Andrea; Campolongo, Patrizia. - STAMPA. - (2016). (Intervento presentato al convegno International Behavioral Neuroscience Society 25° annual meeting tenutosi a Budapest, Hungary).
Perinatal exposure to omega-3 fatty acid imbalance leads to enduring memory alterations in rats
COLUCCI, PAOLA;DE CASTRO, VALENTINA;
2016
Abstract
Perinatal exposure to omega-3 fatty acid imbalance leads to enduring memory alterations in rats Colucci Paola1; De Castro Valentina1; Peloso Andrea1; Campolongo Patrizia1 1Department of Physiology and Pharmacology. Sapienza University of Rome. Rome. Italy Growing evidence shows that long-chain omega-3 fatty acids are crucially involved in brain development and function. Omega-3 fatty acids are extensively added in large amount to several food products and particularly in newborn and infant aliments. Preclinical data show that chronic dietary omega-3 fatty acid deficiency induces behavioral alterations in rodents. Only few studies, instead, have examined the effects of omega-3 fatty acids supplementation on cognitive performances. Therefore, the aim of the present study was to investigate whether chronic dietary omega-3 deprivation or supplementation, during perinatal period, adolescence and adulthood, could affect brain development and function with emphasis on cognitive and emotional processes. The offspring of Sprague Dawley rats, fed with a omega-3 enriched or omega-3 deficient diet throughout mating, pregnancy and lactation, were subjected to a isolation-induced ultrasonic vocalization (USV) emission test and their emissions were compared with calls emitted by normal-nourished pups (control group fed with a diet with balanced omega-3 omega-6 ratio). At PND13, pups from the three exposure groups were tested in the homing test. Adolescent and adult offspring were subjected to the open-field test, elevated plus maze, inhibitory avoidance, and object recognition tests. Significant differences between rats fed with omega-3 enriched or omega-3 deficient diet and the control group were found in USV emission, elevated plus maze and object recognition tests. The present findings suggest that not only a deficiency but also a supplementation of omega-3 fatty acids could induce detrimental effects on brain development leading to enduring behavioral alterations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
