Background. The purpose of this study was to evaluate the tolerability of concurrent radiotherapy and cetuximab (bioradiotherapy [BRT]) after taxane-based induction chemotherapy in head and neck squamous cell carcinoma (HNSCC). Methods. One hundred four patients with HNSCC received BRT with (29%) or without (71%) prior taxane-based induction chemotherapy. Results. Radiodermatitis (97%) and skin rash (65%) occurred frequently, but there was no difference of occurrence or the grade of the rash observed in the 2 populations. However, patients receiving taxane-based induction chemotherapy had a less severe rash as compared with patients without induction chemotherapy. Mucositis and dysphagia were frequent and comparable in the 2 groups. The occurrence of a skin rash (at any grade) did not predict an increased overall survival (OS) in the overall population, but it was associated with an improved 3-year OS in patients receiving taxane-based induction chemotherapy. OS was not influenced by the skin rash grade in the overall population of the 2 treatment subgroups. Conclusion. Taxane-based induction chemotherapy did not increase the rate of cetuximab-related toxicities.

Toxicity of concomitant cetuximab and radiotherapy with or without initial taxane-based induction chemotherapy in locally advanced head and neck cancer / Levy, Antonin; DE FELICE, Francesca; Bellefqih, Sara; Guigay, Joël; Deutsch, Eric; Nguyen, France; Blanchard, Pierre; Tao, Yungan. - In: HEAD & NECK. - ISSN 1043-3074. - STAMPA. - 38:Suppl 1(2016), pp. E905-E910. [10.1002/hed.24125]

Toxicity of concomitant cetuximab and radiotherapy with or without initial taxane-based induction chemotherapy in locally advanced head and neck cancer

DE FELICE, FRANCESCA
Secondo
;
2016

Abstract

Background. The purpose of this study was to evaluate the tolerability of concurrent radiotherapy and cetuximab (bioradiotherapy [BRT]) after taxane-based induction chemotherapy in head and neck squamous cell carcinoma (HNSCC). Methods. One hundred four patients with HNSCC received BRT with (29%) or without (71%) prior taxane-based induction chemotherapy. Results. Radiodermatitis (97%) and skin rash (65%) occurred frequently, but there was no difference of occurrence or the grade of the rash observed in the 2 populations. However, patients receiving taxane-based induction chemotherapy had a less severe rash as compared with patients without induction chemotherapy. Mucositis and dysphagia were frequent and comparable in the 2 groups. The occurrence of a skin rash (at any grade) did not predict an increased overall survival (OS) in the overall population, but it was associated with an improved 3-year OS in patients receiving taxane-based induction chemotherapy. OS was not influenced by the skin rash grade in the overall population of the 2 treatment subgroups. Conclusion. Taxane-based induction chemotherapy did not increase the rate of cetuximab-related toxicities.
2016
cetuximab; chemoradiotherapy; induction chemotherapy; toxicity; otorhinolaryngology; pathology and forensic medicine
01 Pubblicazione su rivista::01a Articolo in rivista
Toxicity of concomitant cetuximab and radiotherapy with or without initial taxane-based induction chemotherapy in locally advanced head and neck cancer / Levy, Antonin; DE FELICE, Francesca; Bellefqih, Sara; Guigay, Joël; Deutsch, Eric; Nguyen, France; Blanchard, Pierre; Tao, Yungan. - In: HEAD & NECK. - ISSN 1043-3074. - STAMPA. - 38:Suppl 1(2016), pp. E905-E910. [10.1002/hed.24125]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/952132
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