Small cell carcinoma of head and neck region (SmCCHN) represents a rare entity and its management remains a significant clinical challenge. Complete initial response to primary therapy poses a difficult and controversial scenario for radiation oncologists. Prophylactic cranial irradiation (PCI) has long been established in the management of small cell lung cancer; however, its role in SmCCHN is still called into question. The rationale behind PCI lies in the eradication of possible micro-metastatic brain disease, which is often documented in this type of cancer. No randomized trials on this topic are available. This review, based on 20 retrospective studies, addresses the controversies in the use of PCI in SmCCHN management.

Controversies in small cell carcinoma of the head and neck: prophylactic cranial irradiation (PCI) after primary complete initial remission / DE FELICE, Francesca; Lei, Mary; Guerrero Urbano, Teresa. - In: CANCER TREATMENT REVIEWS. - ISSN 0305-7372. - STAMPA. - 41:8(2015), pp. 725-728. [10.1016/j.ctrv.2015.05.002]

Controversies in small cell carcinoma of the head and neck: prophylactic cranial irradiation (PCI) after primary complete initial remission

DE FELICE, FRANCESCA
Primo
;
2015

Abstract

Small cell carcinoma of head and neck region (SmCCHN) represents a rare entity and its management remains a significant clinical challenge. Complete initial response to primary therapy poses a difficult and controversial scenario for radiation oncologists. Prophylactic cranial irradiation (PCI) has long been established in the management of small cell lung cancer; however, its role in SmCCHN is still called into question. The rationale behind PCI lies in the eradication of possible micro-metastatic brain disease, which is often documented in this type of cancer. No randomized trials on this topic are available. This review, based on 20 retrospective studies, addresses the controversies in the use of PCI in SmCCHN management.
2015
extrapulmonary; head and neck; prophylactic cranial irradiation; remission; small cell carcinoma; cranial irradiation; humans; remission induction; retrospective studies; treatment outcome; brain neoplasms; carcinoma, small cell; head and neck neoplasms; medicine (all); oncology; radiology, nuclear medicine and imaging
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Controversies in small cell carcinoma of the head and neck: prophylactic cranial irradiation (PCI) after primary complete initial remission / DE FELICE, Francesca; Lei, Mary; Guerrero Urbano, Teresa. - In: CANCER TREATMENT REVIEWS. - ISSN 0305-7372. - STAMPA. - 41:8(2015), pp. 725-728. [10.1016/j.ctrv.2015.05.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/952127
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