Over the last few years a number of new different compounds have been developed. They include phosphatidylinositol 3-kinase (PI3-K) inhibitors. Deregulation within the PI3-K pathway is common in head neck squamous cell carcinoma (HNSCC) and it represents a growing area of research. PI3-K inhibitors, including BKM120, PX-866 and BYL719, are being tested in several phase I and phase II studies in patients with locally advanced, recurrent or metastatic disease. This review provides an update of published clinical trials and highlights the challenges of PI3-K inhibitors in HNSCC. (C) 2017 Elsevier Ltd. All rights reserved.
New drug development in head and neck squamous cell carcinoma: the PI3-K inhibitors / DE FELICE, Francesca; Guerrero Urbano, Teresa. - In: ORAL ONCOLOGY. - ISSN 1368-8375. - STAMPA. - 67:(2017), pp. 119-123. [10.1016/j.oraloncology.2017.02.020]
New drug development in head and neck squamous cell carcinoma: the PI3-K inhibitors
DE FELICE, FRANCESCA
Primo
;
2017
Abstract
Over the last few years a number of new different compounds have been developed. They include phosphatidylinositol 3-kinase (PI3-K) inhibitors. Deregulation within the PI3-K pathway is common in head neck squamous cell carcinoma (HNSCC) and it represents a growing area of research. PI3-K inhibitors, including BKM120, PX-866 and BYL719, are being tested in several phase I and phase II studies in patients with locally advanced, recurrent or metastatic disease. This review provides an update of published clinical trials and highlights the challenges of PI3-K inhibitors in HNSCC. (C) 2017 Elsevier Ltd. All rights reserved.| File | Dimensione | Formato | |
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