We have isolated and studied the expression pattern of Xemx1 and Xerox2 genes in Xenopus laevis. Xemx genes are the homologues of mouse Emx genes, related to Drosophila empty spiracles. They are expressed in selected regions of the developing brain, particularly in the telencephalon, and, outside the brain, in the otic vesicles, olfactory placodes, visceral arches and the developing excretory system. We also report on experiments concerning the tissue and molecular signals responsible for their activation in competent ectoderm. Xerox genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Furthermore, they are not activated in animal caps either by noggin or by Xnr3, thus suggesting that a different inducer or the integration of several signals may be responsible for their activation.

The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals / Pannese, Maria; Lupo, Giuseppe; Kablar, Boris; Boncinelli, Edoardo; Barsacchi, Giuseppina; Vignali, Robert. - In: MECHANISMS OF DEVELOPMENT. - ISSN 0925-4773. - STAMPA. - 73:1(1998), pp. 73-83. [10.1016/S0925-4773(98)00034-3]

The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals

LUPO, GIUSEPPE;
1998

Abstract

We have isolated and studied the expression pattern of Xemx1 and Xerox2 genes in Xenopus laevis. Xemx genes are the homologues of mouse Emx genes, related to Drosophila empty spiracles. They are expressed in selected regions of the developing brain, particularly in the telencephalon, and, outside the brain, in the otic vesicles, olfactory placodes, visceral arches and the developing excretory system. We also report on experiments concerning the tissue and molecular signals responsible for their activation in competent ectoderm. Xerox genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Furthermore, they are not activated in animal caps either by noggin or by Xnr3, thus suggesting that a different inducer or the integration of several signals may be responsible for their activation.
1998
Head organizer; Homeobox genes; Neural induction; Rostral brain patterning; Xenopus; Embryology; Developmental Biology
01 Pubblicazione su rivista::01a Articolo in rivista
The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals / Pannese, Maria; Lupo, Giuseppe; Kablar, Boris; Boncinelli, Edoardo; Barsacchi, Giuseppina; Vignali, Robert. - In: MECHANISMS OF DEVELOPMENT. - ISSN 0925-4773. - STAMPA. - 73:1(1998), pp. 73-83. [10.1016/S0925-4773(98)00034-3]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/950950
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 62
  • ???jsp.display-item.citation.isi??? 57
social impact