The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30. (c) 2006 Elsevier B.V. All rights reserved.

Antiviral activity of substituted homoisoflavonoids on enteroviruses / Sabrina, Tait; Anna Laura, Salvati; Desideri, Nicoletta; Lucia, Fiore. - In: ANTIVIRAL RESEARCH. - ISSN 0166-3542. - 72:3(2006), pp. 252-255. [10.1016/j.antiviral.2006.07.003]

Antiviral activity of substituted homoisoflavonoids on enteroviruses

DESIDERI, Nicoletta;
2006

Abstract

The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30. (c) 2006 Elsevier B.V. All rights reserved.
antivirals; enteroviruses; homoisoflavonoids
01 Pubblicazione su rivista::01a Articolo in rivista
Antiviral activity of substituted homoisoflavonoids on enteroviruses / Sabrina, Tait; Anna Laura, Salvati; Desideri, Nicoletta; Lucia, Fiore. - In: ANTIVIRAL RESEARCH. - ISSN 0166-3542. - 72:3(2006), pp. 252-255. [10.1016/j.antiviral.2006.07.003]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/94948
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 57
social impact