The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30. (c) 2006 Elsevier B.V. All rights reserved.
Antiviral activity of substituted homoisoflavonoids on enteroviruses / Sabrina, Tait; Anna Laura, Salvati; Desideri, Nicoletta; Lucia, Fiore. - In: ANTIVIRAL RESEARCH. - ISSN 0166-3542. - 72:3(2006), pp. 252-255. [10.1016/j.antiviral.2006.07.003]
Antiviral activity of substituted homoisoflavonoids on enteroviruses
DESIDERI, Nicoletta;
2006
Abstract
The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30. (c) 2006 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
