The Somatic Mutation Theory (SMT) has been challenged on its fundamentals by the Tissue Organization Field Theory of Carcinogenesis (TOFT). However, a recent publication has questioned whether TOFT could be a valid alternative theory of carcinogenesis to that presented by SMT. Herein we critically review arguments supporting the irreducible opposition between the two theoretical approaches by highlighting differences regarding the philosophical, methodological and experimental approaches on which they respectively rely. We conclude that SMT has not explained carcinogenesis due to severe epistemological and empirical shortcomings, while TOFT is gaining momentum. The main issue is actually to submit SMT to rigorous testing. This concern includes the imperatives to seek evidence for disproving one’s hypothesis, and to consider the whole, and not just selective evidence.

SMT and TOFT. Why and how they are opposite andi incompatible paradigms / Bizzarri, Mariano; Cucina, Alessandra. - In: ACTA BIOTHEORETICA. - ISSN 0001-5342. - 64:3(2016), pp. 221-239. [10.1007/s10441-016-9281-4]

SMT and TOFT. Why and how they are opposite andi incompatible paradigms

BIZZARRI, Mariano;Cucina, Alessandra
2016

Abstract

The Somatic Mutation Theory (SMT) has been challenged on its fundamentals by the Tissue Organization Field Theory of Carcinogenesis (TOFT). However, a recent publication has questioned whether TOFT could be a valid alternative theory of carcinogenesis to that presented by SMT. Herein we critically review arguments supporting the irreducible opposition between the two theoretical approaches by highlighting differences regarding the philosophical, methodological and experimental approaches on which they respectively rely. We conclude that SMT has not explained carcinogenesis due to severe epistemological and empirical shortcomings, while TOFT is gaining momentum. The main issue is actually to submit SMT to rigorous testing. This concern includes the imperatives to seek evidence for disproving one’s hypothesis, and to consider the whole, and not just selective evidence.
2016
Oncogene; Reductionism; SMT; Systems biology; TOFT; Tumor microenvironment; Carcinogenesis; Humans; Mutation; Neoplasm Proteins; Neoplasms; Algorithms; Models, Biological; Biochemistry, Genetics and Molecular Biology (all); Philosophy; 2300; Agricultural and Biological Sciences (all); Applied Mathematics
01 Pubblicazione su rivista::01a Articolo in rivista
SMT and TOFT. Why and how they are opposite andi incompatible paradigms / Bizzarri, Mariano; Cucina, Alessandra. - In: ACTA BIOTHEORETICA. - ISSN 0001-5342. - 64:3(2016), pp. 221-239. [10.1007/s10441-016-9281-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/945313
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