This paper reports on the development of a lab-on-chip system for detection of DNA through the [Ru(phen)2(dppz)]2+ fluorescent intercalating dye. The device includes on the same glass substrate amorphous silicon photosensors, a thin film interferential filter and a microfluidic network based on polydimethylsiloxane. The suitability of the miniaturized system in detecting the fluorescence variation of the ruthenium complex, working as DNA intercalating molecules, is demonstrated.
Highly miniaturized system for on-chip detection of DNA / Caputo, Domenico; Costantini, Francesca; Lovecchio, Nicola; Viri, V.; Tucci, M.; Mangiapane, P.; Ruggi, A.; Petrucci, Giulia; Nascetti, Augusto; DE CESARE, Giampiero. - STAMPA. - (2016), pp. 1234-1235. (Intervento presentato al convegno 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 tenutosi a Dublin (Ireland) nel 9 -13 October 2016).
Highly miniaturized system for on-chip detection of DNA
CAPUTO, Domenico;COSTANTINI, FRANCESCA;LOVECCHIO, NICOLA;PETRUCCI, GIULIA;NASCETTI, Augusto;DE CESARE, Giampiero
2016
Abstract
This paper reports on the development of a lab-on-chip system for detection of DNA through the [Ru(phen)2(dppz)]2+ fluorescent intercalating dye. The device includes on the same glass substrate amorphous silicon photosensors, a thin film interferential filter and a microfluidic network based on polydimethylsiloxane. The suitability of the miniaturized system in detecting the fluorescence variation of the ruthenium complex, working as DNA intercalating molecules, is demonstrated.| File | Dimensione | Formato | |
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