Objectives. The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods. The study cohort consisted of 32 Caucasian outpatients, giving a total of 64 bilateral symmetrical impacted mandibles. Patients were randomized in two experimental groups to receive a preoperative oral dose of paracetamol-codeine (analgesic group) or a placebo (placebo group) at the first and second surgeries. Study participants were asked to record pain intensity scores during the operation and the next 2 days, the time of the first request for rescue analgesic, and the total number of postoperative-supplement paracetamol-codeine tablets. Results. The pain intensity score on the first day was significantly lower in the analgesic group than in the placebo group . The time to using rescue therapy was significantly longer in the analgesic group than in the placebo group . The number of paracetamol-codeine tablets used postoperatively did not differ between the analgesic and placebo groups . Conclusions. Preoperative paracetamol-codeine is effective in providing immediate postoperative pain control after third molar surgery and in delaying the initial onset of pain. This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03049878.

Efficacy of preoperative administration of paracetamol-codeine on pain following impacted mandibular third molar surgery: a randomized, split-mouth, placebo-controlled, double-blind clinical trial / Cristalli, Maria Paola; La Monaca, Gerardo; De Angelis, Chiara; Pranno, Nicola; Annibali, Susanna. - In: PAIN RESEARCH & MANAGEMENT. - ISSN 1203-6765. - ELETTRONICO. - 2017:(2017), pp. 1-6. [10.1155/2017/9246352]

Efficacy of preoperative administration of paracetamol-codeine on pain following impacted mandibular third molar surgery: a randomized, split-mouth, placebo-controlled, double-blind clinical trial

CRISTALLI, MARIA PAOLA
Primo
;
LA MONACA, Gerardo
Secondo
;
PRANNO, NICOLA
Penultimo
;
ANNIBALI, Susanna
Ultimo
2017

Abstract

Objectives. The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods. The study cohort consisted of 32 Caucasian outpatients, giving a total of 64 bilateral symmetrical impacted mandibles. Patients were randomized in two experimental groups to receive a preoperative oral dose of paracetamol-codeine (analgesic group) or a placebo (placebo group) at the first and second surgeries. Study participants were asked to record pain intensity scores during the operation and the next 2 days, the time of the first request for rescue analgesic, and the total number of postoperative-supplement paracetamol-codeine tablets. Results. The pain intensity score on the first day was significantly lower in the analgesic group than in the placebo group . The time to using rescue therapy was significantly longer in the analgesic group than in the placebo group . The number of paracetamol-codeine tablets used postoperatively did not differ between the analgesic and placebo groups . Conclusions. Preoperative paracetamol-codeine is effective in providing immediate postoperative pain control after third molar surgery and in delaying the initial onset of pain. This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03049878.
2017
postoperative dental pain; quality-of-life; removal; recovery; codeine; paracetamol; placebo
01 Pubblicazione su rivista::01a Articolo in rivista
Efficacy of preoperative administration of paracetamol-codeine on pain following impacted mandibular third molar surgery: a randomized, split-mouth, placebo-controlled, double-blind clinical trial / Cristalli, Maria Paola; La Monaca, Gerardo; De Angelis, Chiara; Pranno, Nicola; Annibali, Susanna. - In: PAIN RESEARCH & MANAGEMENT. - ISSN 1203-6765. - ELETTRONICO. - 2017:(2017), pp. 1-6. [10.1155/2017/9246352]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/939594
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