Starting from a natural cyclopentanoid monoterpene belonging to the class of iridoid glucosides called loganin, we performed the synthesis of a new carbocyclic nucleoside, allowing the preparation of a new lead compound, with a potential HIV antiviral activity as an reverse transcriptase competitive inhibitor that we named LoganVir. The stereocontrol of the coupling reaction was completed utilizing the procedure described by Mitsunobu with a purinic base.
Synthesis of LoganVir, a new carbocyclic nucleoside analogue / Ornano, Luigi; Bianco, Armandodoriano. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - STAMPA. - 30:19(2016), pp. 2164-2172. [10.1080/14786419.2016.1149831]
Synthesis of LoganVir, a new carbocyclic nucleoside analogue
ORNANO, LUIGI;BIANCO, Armandodoriano
2016
Abstract
Starting from a natural cyclopentanoid monoterpene belonging to the class of iridoid glucosides called loganin, we performed the synthesis of a new carbocyclic nucleoside, allowing the preparation of a new lead compound, with a potential HIV antiviral activity as an reverse transcriptase competitive inhibitor that we named LoganVir. The stereocontrol of the coupling reaction was completed utilizing the procedure described by Mitsunobu with a purinic base.File | Dimensione | Formato | |
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