The high incidence of patent foramen ovale (PFO) in migraine with aura (MWA) is well known. In this study we evaluated the relationship between PFO and aura features, and the relative impact of this association on stroke risk. We recruited patients with a diagnosis of MWA. PFO was assessed by contrast transcranial Doppler and confirmed by transoesophageal echocardiography. The 65 patients enrolled were divided into two groups on the basis of the clinical features of their aura: typical in 63.1% (Group 1) and atypical in 36.9% (Group 2). A statistically significant difference was found in PFO prevalence between the two groups (46.3% in Group 1 and 79.2% in Group 2; p=0.009). We did not observe any statistical difference between the two groups in the prevalence of classic stroke risk factors or in the profile of the thrombophilic markers. Our results underline the need to look for PFO particularly in subjects with atypical features of aura, but the underlying pathophysiology of the association is not clear.

Clinical implications of patent foramen ovale in migraine with aura / P., Marchione; N., Ghiotto; G., Sances; E., Guaschino; D., Bosone; G., Nappi; Giacomini, Patrizia. - In: FUNCTIONAL NEUROLOGY. - ISSN 0393-5264. - 23:4(2008), pp. 201-205.

Clinical implications of patent foramen ovale in migraine with aura

GIACOMINI, Patrizia
2008

Abstract

The high incidence of patent foramen ovale (PFO) in migraine with aura (MWA) is well known. In this study we evaluated the relationship between PFO and aura features, and the relative impact of this association on stroke risk. We recruited patients with a diagnosis of MWA. PFO was assessed by contrast transcranial Doppler and confirmed by transoesophageal echocardiography. The 65 patients enrolled were divided into two groups on the basis of the clinical features of their aura: typical in 63.1% (Group 1) and atypical in 36.9% (Group 2). A statistically significant difference was found in PFO prevalence between the two groups (46.3% in Group 1 and 79.2% in Group 2; p=0.009). We did not observe any statistical difference between the two groups in the prevalence of classic stroke risk factors or in the profile of the thrombophilic markers. Our results underline the need to look for PFO particularly in subjects with atypical features of aura, but the underlying pathophysiology of the association is not clear.
2008
migraine with aura; patent foramen ovale; prolonged aura; transcranial doppler
01 Pubblicazione su rivista::01a Articolo in rivista
Clinical implications of patent foramen ovale in migraine with aura / P., Marchione; N., Ghiotto; G., Sances; E., Guaschino; D., Bosone; G., Nappi; Giacomini, Patrizia. - In: FUNCTIONAL NEUROLOGY. - ISSN 0393-5264. - 23:4(2008), pp. 201-205.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/93756
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