..In an intriguing recent paper published in The Journal of Physiology, Fry and colleagues (Fry et al. 2016) explore the potential involvement of SCs and myonuclei apoptosis in young burn patients, a condition characterized by hyper-metabolism and extreme muscle wasting... ...The authors hypothesized that severe burn trauma could induce myonuclear apoptosis along with increased SC activation, in order to counteract the loss of myonuclei. In brief, the major findings by Fry and colleagues were (summarized in Table 1): (1) burn trauma induces myonuclear and SC apoptosis, (2) SC content is decreased although the content of active SCs is increased in burn patients, and (3) the latter two are associated with a generalized regenerative response (increased central nuclei and embMHC positive fibres) in burn patients.

Skeletal muscle stem cell defects in burn-induced cachexia / Farup, Jean; Torcinaro, Alessio; Madaro, Luca. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - ELETTRONICO. - 594:24(2016), pp. 7153-7154. [10.1113/JP273095]

Skeletal muscle stem cell defects in burn-induced cachexia

TORCINARO, ALESSIO;MADARO, LUCA
2016

Abstract

..In an intriguing recent paper published in The Journal of Physiology, Fry and colleagues (Fry et al. 2016) explore the potential involvement of SCs and myonuclei apoptosis in young burn patients, a condition characterized by hyper-metabolism and extreme muscle wasting... ...The authors hypothesized that severe burn trauma could induce myonuclear apoptosis along with increased SC activation, in order to counteract the loss of myonuclei. In brief, the major findings by Fry and colleagues were (summarized in Table 1): (1) burn trauma induces myonuclear and SC apoptosis, (2) SC content is decreased although the content of active SCs is increased in burn patients, and (3) the latter two are associated with a generalized regenerative response (increased central nuclei and embMHC positive fibres) in burn patients.
2016
skeletal muscle; stem cell; cachexia
01 Pubblicazione su rivista::01b Commento, Erratum, Replica e simili
Skeletal muscle stem cell defects in burn-induced cachexia / Farup, Jean; Torcinaro, Alessio; Madaro, Luca. - In: THE JOURNAL OF PHYSIOLOGY. - ISSN 0022-3751. - ELETTRONICO. - 594:24(2016), pp. 7153-7154. [10.1113/JP273095]
File allegati a questo prodotto
File Dimensione Formato  
Farup_Skeletal_2016.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 66.39 kB
Formato Adobe PDF
66.39 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/935632
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact