Editorial: Oxidative stress and Alzheimer disease: where do we stand?

Where do we stand? This question emerges when think- ing of the great number of studies published so far about oxidative stress and Alzheimer disease it becomes clear that the answer to the question is not yet in our hands, despite an extensive knowledge base. After about 30 years since the first intuition (at least by referring to PubMed database) by Martins and colleagues, who proposed the observed increase of glucose-6-phosphate dehydrogenase activity in AD brain as a response to elevated brain peroxide metabolism [1], the discussion on the contribution of oxidative stress to AD on- set and progression is still open.