Reactive oxygen species (ROS) play a pivotal role in different pathologic conditions, including ischemia, diabetes, and aging. We previously showed that ROS enhance miR-200c expression, causing endothelial cell (EC) apoptosis and senescence. Herein, we dissect the interaction among miR-200c and three strictly related proteins that modulate EC function and ROS production: sirtuin 1 (SIRT1), endothelial nitric oxide synthase (eNOS), and forkhead box O1 (FOXO1). Moreover, the role of miR-200c on ROS modulation was also investigated.
Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1, and eNOS / Carlomosti, F., D'Agostino, M., Beji, S., Torcinaro, A., Rizzi, R., Zaccagnini, G., Maimone, B.G., Di Stefano, V., DE SANTA, F., Cordisco, S., Antonini, A., Ciarapica, R., Dellambra, E., Martelli, F., Avitabile, D., Capogrossi, M.C., Magenta, A.. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - 27:6(2017), pp. 328-344. [10.1089/ars.2016.6643]
Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1, and eNOS
CARLOMOSTI, FABRIZIO;d'agostino, marco;BEJI, SARA;TORCINARO, ALESSIO;RIZZI, Roberto;MAIMONE, BIAGINA GIUSEPPA;DE SANTA, Francesca;AVITABILE, DANIELE;MAGENTA, ALESSANDRA
2017
Abstract
Reactive oxygen species (ROS) play a pivotal role in different pathologic conditions, including ischemia, diabetes, and aging. We previously showed that ROS enhance miR-200c expression, causing endothelial cell (EC) apoptosis and senescence. Herein, we dissect the interaction among miR-200c and three strictly related proteins that modulate EC function and ROS production: sirtuin 1 (SIRT1), endothelial nitric oxide synthase (eNOS), and forkhead box O1 (FOXO1). Moreover, the role of miR-200c on ROS modulation was also investigated.| File | Dimensione | Formato | |
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