Tyrosine Kinase inhibitors (TKIs) constitute the most promising frontier of cancer treatment. However, the development of resistance mechanisms often makes the tumour insensitive to TKI-targeted therapy. The present work aims to identify genes and pathways involved in TKI-resistance. To this end, we developed cellular models of NSCLC and designed cellular, molecular and bioinformatics analyses. Preliminary functional enrichment analysis of genes, found consistently altered in resistant cell lines, indicates their involvement in key biological processes.
INTEGRATED ANALYSIS OF DNA COPY NUMBER AND GENE EXPRESSION DATA IN LUNG CANCER MODELS OF RESISTANCE TO TARGETED THERAPY / Fustaino, Valentina; Presutti, D; Cardinali, B; Colombo, T; Papoff, G; Santini, S; Lalli, C; Giannini, G; Brandi, R; Arisi, I; D’Onofrio, M; Felici, G; Ruberti, G.. - (2014), pp. 49-49. (Intervento presentato al convegno IV EURO WG Conference on Operational Research in Computational Biology, Bioinformatics and Medicine Poznan tenutosi a Biedrusko, Poznan nel 26-28/06/2014).
INTEGRATED ANALYSIS OF DNA COPY NUMBER AND GENE EXPRESSION DATA IN LUNG CANCER MODELS OF RESISTANCE TO TARGETED THERAPY
FUSTAINO, VALENTINA;Brandi R;
2014
Abstract
Tyrosine Kinase inhibitors (TKIs) constitute the most promising frontier of cancer treatment. However, the development of resistance mechanisms often makes the tumour insensitive to TKI-targeted therapy. The present work aims to identify genes and pathways involved in TKI-resistance. To this end, we developed cellular models of NSCLC and designed cellular, molecular and bioinformatics analyses. Preliminary functional enrichment analysis of genes, found consistently altered in resistant cell lines, indicates their involvement in key biological processes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
