Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in decision-making of adjuvant therapy for the stage II. This systematic review evaluated the prognostic and/or predictive role of MSI status in patients with stage II colorectal cancer. Only 2 articles fulfilled the eligibility criteria, suggesting a prognostic role of MSI on disease-free survival but not supporting the hypothesis of a predictive effect.
Exploring the Prognostic Role of Microsatellite Instability in Patients With Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis / Romiti, Adriana; Rulli, Eliana; Pilozzi, Emanuela; Gerardi, Chiara; Roberto, Michela; Legramandi, Lorenzo; Falcone, Rosa; Pacchetti, Ilaria; Marchetti, Paolo; Floriani, Irene. - In: CLINICAL COLORECTAL CANCER. - ISSN 1533-0028. - (2016). [10.1016/j.clcc.2016.08.007]
Exploring the Prognostic Role of Microsatellite Instability in Patients With Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis
ROMITI, ADRIANA;PILOZZI, Emanuela;ROBERTO, MICHELA;FALCONE, ROSA;MARCHETTI, PAOLO;
2016
Abstract
Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in decision-making of adjuvant therapy for the stage II. This systematic review evaluated the prognostic and/or predictive role of MSI status in patients with stage II colorectal cancer. Only 2 articles fulfilled the eligibility criteria, suggesting a prognostic role of MSI on disease-free survival but not supporting the hypothesis of a predictive effect.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
