Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in decision-making of adjuvant therapy for the stage II. This systematic review evaluated the prognostic and/or predictive role of MSI status in patients with stage II colorectal cancer. Only 2 articles fulfilled the eligibility criteria, suggesting a prognostic role of MSI on disease-free survival but not supporting the hypothesis of a predictive effect.

Exploring the Prognostic Role of Microsatellite Instability in Patients With Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis

ROMITI, ADRIANA;PILOZZI, Emanuela;ROBERTO, MICHELA;FALCONE, ROSA;MARCHETTI, PAOLO;
2016

Abstract

Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in decision-making of adjuvant therapy for the stage II. This systematic review evaluated the prognostic and/or predictive role of MSI status in patients with stage II colorectal cancer. Only 2 articles fulfilled the eligibility criteria, suggesting a prognostic role of MSI on disease-free survival but not supporting the hypothesis of a predictive effect.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/932564
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