BACKGROUND: Early onset (≤50y) colorectal carcinomas (EO-CRCs) are increasing in incidence according to epidemiological data. We investigated clinical-pathological, molecular features and outcomes of 62 left sided EO-CRCs (EOLS-CRCs) and compared them to a group of late onset (≥65) LS-CRCs (LOLS-CRCs). MATERIALS AND METHODS: Samples were evaluated for pathological features and microsatellite instability (MSI). Overall survival (OS), disease free survival (DFS) and disease specific survival were evaluated in both groups. RESULTS: Five out 62 (8%) EOLS-CRCs showed MSI phenotype. Interestingly these cases were aged 26-39y. Most EOLS-CRCs present at advanced stage and this was statistically significant when compared to LOLS-CRCs. OS was better in EOLS-CRCs whilst DFS showed a worst profile in EOLS-CRCs either in low and high stages even though young patients were treated more often with adjuvant chemotherapy compared to older ones at the same disease stage. CONCLUSIONS: Most EOLS-CRCs are sporadic non Lynch, microsatellite stable (MSS) CRCs. Our data show that when compared with LOLS-CRCs the early group represents an aggressive disease with worst outcome underlining a possible different carcinogenic pathway.
Left-sided early onset colorectal carcinomas: a sporadic neoplasm with aggressive behavior / Pilozzi, Emanuela; Lorenzon, Laura; LO BAIDO, Simone; Ferri, Mario; Duranti, Enrico; Fochetti, Flavio; Mercantini, Paolo; Ramacciato, Giovanni; Balducci, Genoveffa; Ruco, Luigi. - In: THE AMERICAN JOURNAL OF SURGERY. - ISSN 0002-9610. - STAMPA. - 214:3(2017), pp. 421-427. [10.1016/j.amjsurg.2017.01.035]
Left-sided early onset colorectal carcinomas: a sporadic neoplasm with aggressive behavior
PILOZZI, Emanuela
;LORENZON, LAURA;LO BAIDO, SIMONE;FERRI, Mario;DURANTI, Enrico;FOCHETTI, FLAVIO;MERCANTINI, Paolo;RAMACCIATO, Giovanni;BALDUCCI, Genoveffa;RUCO, Luigi
2017
Abstract
BACKGROUND: Early onset (≤50y) colorectal carcinomas (EO-CRCs) are increasing in incidence according to epidemiological data. We investigated clinical-pathological, molecular features and outcomes of 62 left sided EO-CRCs (EOLS-CRCs) and compared them to a group of late onset (≥65) LS-CRCs (LOLS-CRCs). MATERIALS AND METHODS: Samples were evaluated for pathological features and microsatellite instability (MSI). Overall survival (OS), disease free survival (DFS) and disease specific survival were evaluated in both groups. RESULTS: Five out 62 (8%) EOLS-CRCs showed MSI phenotype. Interestingly these cases were aged 26-39y. Most EOLS-CRCs present at advanced stage and this was statistically significant when compared to LOLS-CRCs. OS was better in EOLS-CRCs whilst DFS showed a worst profile in EOLS-CRCs either in low and high stages even though young patients were treated more often with adjuvant chemotherapy compared to older ones at the same disease stage. CONCLUSIONS: Most EOLS-CRCs are sporadic non Lynch, microsatellite stable (MSS) CRCs. Our data show that when compared with LOLS-CRCs the early group represents an aggressive disease with worst outcome underlining a possible different carcinogenic pathway.File | Dimensione | Formato | |
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