The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open and generalized entity, whose contour appears less defined as compared to the past. Here we propose the essence of the gene to be considered double faced. In this respect genotypic and phenotypic entities of a gene would coexist and mix reciprocally. This harmonizes present knowledge with current definitions and predisposes for remodelling of our thinking as a consequence of future discoveries. A two sided view of the gene also allows to combine the genetic and epigenetic aspects in a unique solution, being structural and functional at the same time and simultaneously able to include the different levels in an overlapping unicum.
What is a Gene? A Two Sided View / Bolondi, A.; Caldarelli, F.; DI FELICE, Francesca; Durano, Diletta; Germani, G.; Michetti, L.; Tramutolo, A.; Micheli, G.; Camilloni, Giorgio. - In: EVOLUTIONARY BIOLOGY. - ISSN 0071-3260. - STAMPA. - 44:(2017), pp. 1-4. [10.1007/s11692-016-9392-5]
What is a Gene? A Two Sided View
DI FELICE, Francesca;DURANO, DILETTA;CAMILLONI, Giorgio
2017
Abstract
The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open and generalized entity, whose contour appears less defined as compared to the past. Here we propose the essence of the gene to be considered double faced. In this respect genotypic and phenotypic entities of a gene would coexist and mix reciprocally. This harmonizes present knowledge with current definitions and predisposes for remodelling of our thinking as a consequence of future discoveries. A two sided view of the gene also allows to combine the genetic and epigenetic aspects in a unique solution, being structural and functional at the same time and simultaneously able to include the different levels in an overlapping unicum.File | Dimensione | Formato | |
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