MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plastic- ity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity / Capitano, F.; Camon, J.; Licursi, V.; Ferretti, V.; Maggi, L.; Scianni, M.; Del Vecchio, G.; Rinaldi, A.; Mannironi, C.; Limatola, C.; Presutti, C.; Mele, A.. - In: NEUROBIOLOGY OF LEARNING AND MEMORY. - ISSN 1074-7427. - STAMPA. - 139:(2017), pp. 63-68. [10.1016/j.nlm.2016.12.019]

MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

Capitano, F.;Camon, J.;Licursi, V.;Ferretti, V.;Maggi, L.;Scianni, M.;Del Vecchio, G.;Rinaldi, A.;Limatola, C.;Presutti, C.;Mele, A.
2017

Abstract

MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plastic- ity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.
2017
LTP; Mice; Morris water maze; Experimental and Cognitive Psychology; Cognitive Neuroscience; Behavioral Neuroscience
01 Pubblicazione su rivista::01a Articolo in rivista
MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity / Capitano, F.; Camon, J.; Licursi, V.; Ferretti, V.; Maggi, L.; Scianni, M.; Del Vecchio, G.; Rinaldi, A.; Mannironi, C.; Limatola, C.; Presutti, C.; Mele, A.. - In: NEUROBIOLOGY OF LEARNING AND MEMORY. - ISSN 1074-7427. - STAMPA. - 139:(2017), pp. 63-68. [10.1016/j.nlm.2016.12.019]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/929601
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