A case of a patient with an uncommon thyroid carcinoma, showing histological and immunohistochemical features of both follicular and parafollicular cells is described. Somatic point mutation (ATG to ACG heterozygotic mutation at codon 918) of the RET proto-oncogene was detected in tumor tissue, as confirmed by immunohistochemical expression of RET oncoprotein. Our findings suggest that constitutive RET proto-oncogene activation may be involved in the development of mixed medullary-follicular thyroid carcinoma. (C) 2001, Editrice Kurtis.

RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma / F., Orlandi; E., Chiefari; P., Caraci; A., Mussa; I., Gonzatto; P., De Giuli; D., Giuffrida; A., Angeli; Filetti, Sebastiano. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 24:1(2001), pp. 51-55.

RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma

FILETTI, SEBASTIANO
2001

Abstract

A case of a patient with an uncommon thyroid carcinoma, showing histological and immunohistochemical features of both follicular and parafollicular cells is described. Somatic point mutation (ATG to ACG heterozygotic mutation at codon 918) of the RET proto-oncogene was detected in tumor tissue, as confirmed by immunohistochemical expression of RET oncoprotein. Our findings suggest that constitutive RET proto-oncogene activation may be involved in the development of mixed medullary-follicular thyroid carcinoma. (C) 2001, Editrice Kurtis.
2001
mixed thyroid carcinoma; ret oncogene; thyroid neoplasm
01 Pubblicazione su rivista::01a Articolo in rivista
RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma / F., Orlandi; E., Chiefari; P., Caraci; A., Mussa; I., Gonzatto; P., De Giuli; D., Giuffrida; A., Angeli; Filetti, Sebastiano. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 24:1(2001), pp. 51-55.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/92725
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